An assessment of adalimumab efficacy in three Phase III clinical trials using the European Consensus Programme criteria for psoriasis treatment goals

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  • U Mrowietz
  • ,
  • K Kragballe, Denmark
  • K Reich
  • ,
  • C E M Griffiths
  • ,
  • Ying Gu, Institut for Medicin og Sundhedsteknologi, Denmark
  • Y Wang, Denmark
  • S J Rozzo
Background  The European Consensus Programme (ECP) established pan-European consensus definitions of psoriasis disease severity and treatment goals among 19 psoriasis experts from European nations. Objectives  To use the ECP treatment goals to retrospectively assess adalimumab efficacy in patients who participated in Phase III clinical trials and met ECP criteria for moderate to severe psoriasis. Methods  Three trials were analysed: CHAMPION (n = 108), REVEAL (n = 814) and BELIEVE (n = 364). Moderate to severe psoriasis was defined as Dermatology Life Quality Index (DLQI) score > 10, with either > 10% body surface area involvement or Psoriasis Area and Severity Index (PASI) score > 10. Treatment goals were achieved with either treatment success (≥ 75% PASI score reduction) or intermediate response (PASI response ≥ 50% and  93% of patients who attained treatment goals. At week 16 > 70% of patients achieved ECP treatment goals and met ECP criteria for continued treatment without modification. These results support the utility of ECP treatment goals for the assessment of therapeutic efficacy in moderate to severe psoriasis.
Original languageEnglish
JournalBritish Journal of Dermatology
Volume168
Issue2
Pages (from-to)374-80
Number of pages7
ISSN0007-0963
DOIs
Publication statusPublished - 2013

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