Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study

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DOI

  • Hilary A. Archer, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Paul Edison, Hammersmith Hospital
  • ,
  • David J. Brooks
  • Jo Barnes, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Chris Frost, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, London School of Hygiene and Tropical Medicine
  • ,
  • Tom Yeatman, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Nick C. Fox, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Martin N. Rossor, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. 11C-PIB( 11C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional 11C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

Original languageEnglish
JournalAnnals of Neurology
Volume60
Issue1
Pages (from-to)145-147
Number of pages3
ISSN0364-5134
DOIs
Publication statusPublished - 1 Jul 2006
Externally publishedYes

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