Amplification-free liquid biopsy by fluorescence approach

Research output: Contribution to book/anthology/report/proceedingArticle in proceedingsResearchpeer-review

  • Jesper Uhd, Syddansk universitet
  • ,
  • Anders Okholm
  • ,
  • Jargen Kjems
  • Kira Astakhova, Syddansk universitet

Liquid biopsy is an attractive new paradigm of modern cancer research and clinical oncology. Synergy of fluorescence microscopy with mutation specific molecular probes is a method that we developed for the detection of tumor related circulating DNA, ctDNA. The present detection methods of ctDNA samples include amplification-based techniques that have multiple challenges, are often time consuming and rather expensive. In this work, we successfully applied the hybridization assay and advanced microscopy for the reliable amplification-free detection and quantification of cancer associated mutations in ctDNA.

Original languageEnglish
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2017
Number of pages4
Volume3
PublisherTechConnect
Publication year1 Jan 2017
Pages106-109
ISBN (Electronic)9780998878201
Publication statusPublished - 1 Jan 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: 14 May 201717 May 2017

Conference

Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
LandUnited States
ByWashington
Periode14/05/201717/05/2017

    Research areas

  • Bioconjugation, CtDNA, Fluorescence microscopy, Mutation detection, Nucleic acid

See relations at Aarhus University Citationformats

ID: 121326522