Ammonia toxicity: from head to toe?

Srinivasan Dasarathy; Rajeshwar P Mookerjee; Veronika Rackayova; Vinita Rangroo Thrane; Balasubramaniyan Vairappan; Peter Ott; Christopher F Rose

doi:10.1007/s11011-016-9938-3

Ammonia toxicity: from head to toe?

Srinivasan Dasarathy, Rajeshwar P Mookerjee, Veronika Rackayova, Vinita Rangroo Thrane, Balasubramaniyan Vairappan, Peter Ott, Christopher F Rose

Department of Clinical Medicine - Hepatology and Gastroenterology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

190 Citations (Scopus)

Abstract

Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause neurological impairment. However, the deleterious effects of ammonia are not specific to the brain, as the direct effect of increased ammonia (change in pH, membrane potential, metabolism) can occur in any type of cell. Therefore, in the setting of chronic liver disease where multi-organ dysfunction is common, the role of ammonia, only as neurotoxin, is challenged. This review provides insights and evidence that increased ammonia can disturb many organ and cell types and hence lead to dysfunction.

Original language	English
Journal	Metabolic Brain Disease
Volume	32
Issue	2
Pages (from-to)	529-538
Number of pages	10
ISSN	0885-7490
DOIs	https://doi.org/10.1007/s11011-016-9938-3
Publication status	Published - Apr 2017

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10.1007/s11011-016-9938-3

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title = "Ammonia toxicity: from head to toe?",

abstract = "Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause neurological impairment. However, the deleterious effects of ammonia are not specific to the brain, as the direct effect of increased ammonia (change in pH, membrane potential, metabolism) can occur in any type of cell. Therefore, in the setting of chronic liver disease where multi-organ dysfunction is common, the role of ammonia, only as neurotoxin, is challenged. This review provides insights and evidence that increased ammonia can disturb many organ and cell types and hence lead to dysfunction.",

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AU - Dasarathy, Srinivasan

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AU - Rackayova, Veronika

AU - Rangroo Thrane, Vinita

AU - Vairappan, Balasubramaniyan

AU - Ott, Peter

AU - Rose, Christopher F

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Ammonia toxicity: from head to toe?

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