AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up

Casper P Hagen; Margit Bistrup Fischer; Gylli Mola; Theis Bech Mikkelsen; Line Hartvig Cleemann; Claus Højbjerg Gravholt; Mette H Viuff; Anders Juul; Anette Tønnes Pedersen; Katharina Maria Main

doi:10.3389/fendo.2023.1173600

AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up

Casper P Hagen^*
, Margit Bistrup Fischer
, Gylli Mola
, Theis Bech Mikkelsen
, Line Hartvig Cleemann
, Claus Højbjerg Gravholt
, Mette H Viuff
, Anders Juul
, Anette Tønnes Pedersen
, Katharina Maria Main

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

8 Citations (Scopus)

Abstract

Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark.

Original language	English
Article number	1173600
Journal	Frontiers in Endocrinology
Volume	14
Number of pages	17
ISSN	1664-2392
DOIs	https://doi.org/10.3389/fendo.2023.1173600
Publication status	Published - Jun 2023

Keywords

Adult
Pregnancy
Child
Female
Humans
Turner Syndrome
Follow-Up Studies
Ovary
Longitudinal Studies
Puberty
anti mullerian hormone (AMH)
FSH (Follicle Stimulating Hormone)
ovarian function
fertility preservation
inhibin B
turner syndrome

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Hagen, C. P., Fischer, M. B., Mola, G., Mikkelsen, T. B., Cleemann, L. H., Gravholt, C. H., Viuff, M. H., Juul, A., Pedersen, A. T., & Main, K. M. (2023). AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up. Frontiers in Endocrinology, 14, Article 1173600. https://doi.org/10.3389/fendo.2023.1173600

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title = "AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up",

abstract = "Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50\% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10\% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark.",

keywords = "Adult, Pregnancy, Child, Female, Humans, Turner Syndrome, Follow-Up Studies, Ovary, Longitudinal Studies, Puberty, anti mullerian hormone (AMH), FSH (Follicle Stimulating Hormone), ovarian function, fertility preservation, inhibin B, turner syndrome",

author = "Hagen, \{Casper P\} and Fischer, \{Margit Bistrup\} and Gylli Mola and Mikkelsen, \{Theis Bech\} and Cleemann, \{Line Hartvig\} and Gravholt, \{Claus H{\o}jbjerg\} and Viuff, \{Mette H\} and Anders Juul and Pedersen, \{Anette T{\o}nnes\} and Main, \{Katharina Maria\}",

note = "Copyright {\textcopyright} 2023 Hagen, Fischer, Mola, Mikkelsen, Cleemann, Gravholt, Viuff, Juul, Pedersen and Main.",

year = "2023",

month = jun,

doi = "10.3389/fendo.2023.1173600",

language = "English",

volume = "14",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media SA",

}

Hagen, CP, Fischer, MB, Mola, G, Mikkelsen, TB, Cleemann, LH, Gravholt, CH, Viuff, MH, Juul, A, Pedersen, AT & Main, KM 2023, 'AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up', Frontiers in Endocrinology, vol. 14, 1173600. https://doi.org/10.3389/fendo.2023.1173600

AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up. / Hagen, Casper P; Fischer, Margit Bistrup; Mola, Gylli et al.
In: Frontiers in Endocrinology, Vol. 14, 1173600, 06.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

TY - JOUR

T1 - AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up

AU - Hagen, Casper P

AU - Fischer, Margit Bistrup

AU - Mola, Gylli

AU - Mikkelsen, Theis Bech

AU - Cleemann, Line Hartvig

AU - Gravholt, Claus Højbjerg

AU - Viuff, Mette H

AU - Juul, Anders

AU - Pedersen, Anette Tønnes

AU - Main, Katharina Maria

PY - 2023/6

Y1 - 2023/6

N2 - Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark.

AB - Turner syndrome (TS) is a chromosomal disorder that affects about 1 in 2500 female births and is characterized by the partial or complete absence of the second X chromosome. Depending on karyotype, TS is associated with primary ovarian insufficiency (POI). Approximately 50% of girls with a mosaic 45, X/46, XX karyotype may enter puberty spontaneously, but only 5-10% of women with TS achieve pregnancy without egg donation. In this review, we will evaluate the clinical use of markers of ovarian function in TS patients. Based on longitudinal studies of serum concentrations of reproductive hormones as well as ovarian morphology in healthy females and patients with TS, we will evaluate how they can be applied in a clinical setting. This is important when counseling patients and their families about future ovarian function essential for pubertal development and fertility. Furthermore, we will report on 20 years of experience of transition from pediatric to gynecological and adult endocrinological care in our center at Rigshospitalet, Copenhagen, Denmark.

KW - Adult

KW - Pregnancy

KW - Child

KW - Female

KW - Humans

KW - Turner Syndrome

KW - Follow-Up Studies

KW - Ovary

KW - Longitudinal Studies

KW - Puberty

KW - anti mullerian hormone (AMH)

KW - FSH (Follicle Stimulating Hormone)

KW - ovarian function

KW - fertility preservation

KW - inhibin B

KW - turner syndrome

UR - https://www.scopus.com/pages/publications/85164920774

U2 - 10.3389/fendo.2023.1173600

DO - 10.3389/fendo.2023.1173600

M3 - Review

C2 - 37455919

SN - 1664-2392

VL - 14

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 1173600

ER -

AMH and other markers of ovarian function in patients with Turner syndrome - a single center experience of transition from pediatric to gynecological follow up

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