Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Yong-Ming Wang, Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, PR China; Sino-Danish Center for Education and Research, Beijing 100190, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
  • ,
  • Lai-Quan Zou, Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Department of Psychology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, Guangdong, PR China.
  • ,
  • Wen-Lan Xie, Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
  • ,
  • Zhuo-Ya Yang, Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China.
  • ,
  • Xiong-Zhao Zhu, Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, PR China.
  • ,
  • Eric F C Cheung, Castle Peak Hospital, Hong Kong Special Administrative Region, PR China.
  • ,
  • Thomas Alrik Sørensen
  • Arne Møller
  • Raymond C K Chan, Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, PR China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, PR China; Sino-Danish Center for Education and Research, Beijing 100190, PR China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, PR China. Electronic address: rckchan@psych.ac.cn.

Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.

Original languageEnglish
JournalPsychiatry Research
Volume276
Pages (from-to)65-72
Number of pages8
ISSN0165-1781
DOIs
Publication statusPublished - Jun 2018

    Research areas

  • Cortical thickness, Grey matter volume, Obsessive-compulsive disorder, Schizo-obsessive comorbidity, Schizophrenia

See relations at Aarhus University Citationformats

ID: 125954188