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Altered evoked responses for motor-related words in children with upper limb motor impairments

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  • Dimitri Bredikhin, Higher School of Economics
  • ,
  • Olga Agranovich, Russian Ministry of Health
  • ,
  • Maxim Ulanov, Higher School of Economics
  • ,
  • Maria Koriakina, Higher School of Economics, Russian Ministry of Health
  • ,
  • Anna N. Shestakova, Higher School of Economics
  • ,
  • Dzerassa Kadieva, Higher School of Economics
  • ,
  • Grigory Kopytin, Higher School of Economics
  • ,
  • Evgenia Ermolovich, Russian Ministry of Health
  • ,
  • Beatriz Bermúdez-Margaretto, Higher School of Economics, Universidad de Salamanca
  • ,
  • Yury Shtyrov
  • Iiro P. Jääskeläinen, Higher School of Economics, Aalto University
  • ,
  • Evgeny Blagovechtchenski, Higher School of Economics, Russian Ministry of Health

Objective: Obstetric brachial plexus palsy (OBPP) and amyoplasia, the classical type of arthrogryposis multiplex congenita, manifest themselves as highly limited mobility of the upper limb. At the same time, according to the embodiment cognition theories, the motor impairments might lead to the alteration of cognitive functions in OBPP/amyoplasia patients. In the current study, we examined whether OBPP/amyoplasia children exhibit altered processing of motor-related verbs. Methods: We conducted a case-control study using clinical population and control children. Oddball series were used to elicit mismatch negativity (MMN) EEG responses. The series consisted of limb-related verbs (deviant stimuli) and matched pseudowords (standard stimuli). 27 patients and 32 control children were included in the analysis. Results: We showed that MMN waveforms differed between OBPP/amyoplasia children and their control peers in the frontal and temporal electrodes when the stimuli contained hand-related verbs. In particular, the MMN peak latency in the OBPP/amyoplasia children was significantly delayed as compared with the healthy controls. At the same time, neither series with leg-related verbs nor series of pseudowords resulted in statistically significant differences. Conclusions: Our findings suggest altered processing of hand-related verbs in OBPP/amyoplasia children with hand-related disabilities. Significance: Our results contribute to the growing evidence in support of the theory of embodied cognition, which proposes that various domains of cognition are shaped by bodily interactions with the environment.

Original languageEnglish
JournalClinical Neurophysiology
Pages (from-to)11-21
Number of pages11
Publication statusPublished - Jan 2023

    Research areas

  • Arthrogryposis multiplex congenita, EEG, Embodied cognition, Hand movements, Mismatch negativity, Obstetric brachial plexus palsy

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