Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

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Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. / Figueroa, Caroline A.; Cabral, Joana; Mocking, Roel J.T.; Rapuano, Kristina M.; van Hartevelt, Tim J.; Deco, Gustavo; Expert, Paul; Schene, Aart H.; Kringelbach, Morten L.; Ruhé, Henricus G.

In: Human Brain Mapping, Vol. 40, No. 9, 2019, p. 2771-2786.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Figueroa, CA, Cabral, J, Mocking, RJT, Rapuano, KM, van Hartevelt, TJ, Deco, G, Expert, P, Schene, AH, Kringelbach, ML & Ruhé, HG 2019, 'Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder', Human Brain Mapping, vol. 40, no. 9, pp. 2771-2786. https://doi.org/10.1002/hbm.24559

APA

Figueroa, C. A., Cabral, J., Mocking, R. J. T., Rapuano, K. M., van Hartevelt, T. J., Deco, G., Expert, P., Schene, A. H., Kringelbach, M. L., & Ruhé, H. G. (2019). Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. Human Brain Mapping, 40(9), 2771-2786. https://doi.org/10.1002/hbm.24559

CBE

Figueroa CA, Cabral J, Mocking RJT, Rapuano KM, van Hartevelt TJ, Deco G, Expert P, Schene AH, Kringelbach ML, Ruhé HG. 2019. Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. Human Brain Mapping. 40(9):2771-2786. https://doi.org/10.1002/hbm.24559

MLA

Vancouver

Figueroa CA, Cabral J, Mocking RJT, Rapuano KM, van Hartevelt TJ, Deco G et al. Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. Human Brain Mapping. 2019;40(9):2771-2786. https://doi.org/10.1002/hbm.24559

Author

Figueroa, Caroline A. ; Cabral, Joana ; Mocking, Roel J.T. ; Rapuano, Kristina M. ; van Hartevelt, Tim J. ; Deco, Gustavo ; Expert, Paul ; Schene, Aart H. ; Kringelbach, Morten L. ; Ruhé, Henricus G. / Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. In: Human Brain Mapping. 2019 ; Vol. 40, No. 9. pp. 2771-2786.

Bibtex

@article{8609db4d43854e14826726a2540acf82,
title = "Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder",
abstract = "Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self-referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted-MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.",
keywords = "cognitive control, dynamic FC, functional networks, major depressive disorder, resting-state fMRI",
author = "Figueroa, {Caroline A.} and Joana Cabral and Mocking, {Roel J.T.} and Rapuano, {Kristina M.} and {van Hartevelt}, {Tim J.} and Gustavo Deco and Paul Expert and Schene, {Aart H.} and Kringelbach, {Morten L.} and Ruh{\'e}, {Henricus G.}",
year = "2019",
doi = "10.1002/hbm.24559",
language = "English",
volume = "40",
pages = "2771--2786",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "JohnWiley & Sons, Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

AU - Figueroa, Caroline A.

AU - Cabral, Joana

AU - Mocking, Roel J.T.

AU - Rapuano, Kristina M.

AU - van Hartevelt, Tim J.

AU - Deco, Gustavo

AU - Expert, Paul

AU - Schene, Aart H.

AU - Kringelbach, Morten L.

AU - Ruhé, Henricus G.

PY - 2019

Y1 - 2019

N2 - Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self-referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted-MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.

AB - Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self-referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted-MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.

KW - cognitive control

KW - dynamic FC

KW - functional networks

KW - major depressive disorder

KW - resting-state fMRI

UR - http://www.scopus.com/inward/record.url?scp=85062938250&partnerID=8YFLogxK

U2 - 10.1002/hbm.24559

DO - 10.1002/hbm.24559

M3 - Journal article

C2 - 30864248

AN - SCOPUS:85062938250

VL - 40

SP - 2771

EP - 2786

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 9

ER -