Aarhus University Seal

Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


  • hbm.24559

    Final published version, 32.8 MB, PDF document


  • Caroline A. Figueroa, University of Amsterdam, University of California at Berkeley
  • ,
  • Joana Cabral
  • Roel J.T. Mocking, University of Amsterdam
  • ,
  • Kristina M. Rapuano, Department of Psychological and Brain Sciences, Dartmouth College
  • ,
  • Tim J. van Hartevelt, University of Oxford
  • ,
  • Gustavo Deco, Pompeu Fabra University, Theoretical and Computational Neuroscience Group, Center of Brain and Cognition, Universitat Pompeu Fabra, 08018 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain., Max Planck Institute for Human Cognitive and Brain Sciences, Monash University
  • ,
  • Paul Expert, Imperial College London
  • ,
  • Aart H. Schene, University of Amsterdam, Radboud University Nijmegen
  • ,
  • Morten L. Kringelbach
  • Henricus G. Ruhé, University of Amsterdam, University of Oxford, Radboud University Nijmegen

Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self-referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted-MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.

Original languageEnglish
JournalHuman Brain Mapping
Pages (from-to)2771-2786
Number of pages16
Publication statusPublished - 2019

    Research areas

  • cognitive control, dynamic FC, functional networks, major depressive disorder, resting-state fMRI

See relations at Aarhus University Citationformats

Download statistics

No data available

ID: 153709301