Department of Economics and Business Economics

Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study

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  • National Centre for Register-based Research
To cite this article: Qin P, Mortensen PB, Waltoft BL, Postolache TT. Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study. Allergy 2011; 66: 658-664. ABSTRACT: Background:  With increasing research suggesting a role of allergy on suicidality, this study, on a population level, delved into how allergy affects risk for suicide completion in the context of mood disorder and other factors. Methods:  Based on the entire population of Denmark, we included 27 096 completed suicides and 467 571 live controls matched on sex and age with a nested case-control design. We retrieved personal information on hospital contacts for allergy and other variables from various Danish longitudinal registries and analyzed the data with conditional logistic regression. Results:  We noted that 1.17% suicide victims, compared with 0.79% matched controls, had a history of hospital contact for allergy and that a history of allergy predicted an increased risk for suicide completion; however, the effect was confined to allergy that led to inpatient treatment (IRR: 1.59, 95% CI: 1.41-1.80). The increased risk was attenuated somewhat but remained significant when adjusted for personal psychiatric history and socioeconomic status. Meanwhile, we observed a nonsignificantly stronger effect in women than in men, and a significant age difference with a stronger effect for individuals at high ages. Moreover, we detected a significant interaction between allergy and mood disorder - even an antagonism effect of the two exposures. Allergy increased suicide risk only in persons with no history of mood disorder, whereas it eliminated suicide risk in those with a history of mood disorder. Conclusions:  The findings support a link between allergy and suicidality, with a possible mediating role of mood disorder.
Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume66
Issue5
Pages (from-to)658-64
Number of pages7
ISSN0105-4538
DOIs
Publication statusPublished - 1 May 2011

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