Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH

Casper Jon Steenbjerg Ibsen; Hanna Leemreize; Bjørn Fridur Mikladal; Jonas Skovgaard; Martin Bremholm; Jacob Rostgaard Eltzholtz; Bo Brummerstedt Iversen; Henrik Birkedal

doi:10.1021/acs.cgd.8b01008

Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH

Casper Jon Steenbjerg Ibsen, Hanna Leemreize, Bjørn Fridur Mikladal, Jonas Skovgaard, Martin Bremholm, Jacob Rostgaard Eltzholtz, Bo Brummerstedt Iversen, Henrik Birkedal^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

16 Citations (Scopus)

Abstract

Crystallization from amorphous precursors emerges as a major principle in biomineralization, but the mechanisms and kinetics involved remain unclear for many materials. Herein, we used in situ synchrotron X-ray diffraction to study crystallization of apatite from amorphous calcium phosphate at a pH where the solution is dominated by phosphate to circumvent the formation of acidic calcium phosphates. The initial crystals were almost isometric. Highly anisotropic growth resulted in needle shaped crystals at later times. Changing the counterion from sodium to potassium lead to changes in nucleation time, growth speed, and nanocrystal shape but preserved the overall crystallization mechanism.

Original language	English
Journal	Crystal Growth and Design
Volume	18
Issue	11
Pages (from-to)	6723-6728
Number of pages	6
ISSN	1528-7483
DOIs	https://doi.org/10.1021/acs.cgd.8b01008
Publication status	Published - 1 Nov 2018

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title = "Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH",

abstract = "Crystallization from amorphous precursors emerges as a major principle in biomineralization, but the mechanisms and kinetics involved remain unclear for many materials. Herein, we used in situ synchrotron X-ray diffraction to study crystallization of apatite from amorphous calcium phosphate at a pH where the solution is dominated by phosphate to circumvent the formation of acidic calcium phosphates. The initial crystals were almost isometric. Highly anisotropic growth resulted in needle shaped crystals at later times. Changing the counterion from sodium to potassium lead to changes in nucleation time, growth speed, and nanocrystal shape but preserved the overall crystallization mechanism.",

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Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH. / Ibsen, Casper Jon Steenbjerg; Leemreize, Hanna; Mikladal, Bjørn Fridur et al.
In: Crystal Growth and Design, Vol. 18, No. 11, 01.11.2018, p. 6723-6728.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH

AU - Ibsen, Casper Jon Steenbjerg

AU - Leemreize, Hanna

AU - Mikladal, Bjørn Fridur

AU - Skovgaard, Jonas

AU - Bremholm, Martin

AU - Eltzholtz, Jacob Rostgaard

AU - Iversen, Bo Brummerstedt

AU - Birkedal, Henrik

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Crystallization from amorphous precursors emerges as a major principle in biomineralization, but the mechanisms and kinetics involved remain unclear for many materials. Herein, we used in situ synchrotron X-ray diffraction to study crystallization of apatite from amorphous calcium phosphate at a pH where the solution is dominated by phosphate to circumvent the formation of acidic calcium phosphates. The initial crystals were almost isometric. Highly anisotropic growth resulted in needle shaped crystals at later times. Changing the counterion from sodium to potassium lead to changes in nucleation time, growth speed, and nanocrystal shape but preserved the overall crystallization mechanism.

AB - Crystallization from amorphous precursors emerges as a major principle in biomineralization, but the mechanisms and kinetics involved remain unclear for many materials. Herein, we used in situ synchrotron X-ray diffraction to study crystallization of apatite from amorphous calcium phosphate at a pH where the solution is dominated by phosphate to circumvent the formation of acidic calcium phosphates. The initial crystals were almost isometric. Highly anisotropic growth resulted in needle shaped crystals at later times. Changing the counterion from sodium to potassium lead to changes in nucleation time, growth speed, and nanocrystal shape but preserved the overall crystallization mechanism.

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U2 - 10.1021/acs.cgd.8b01008

DO - 10.1021/acs.cgd.8b01008

M3 - Journal article

AN - SCOPUS:85054686637

SN - 1528-7483

VL - 18

SP - 6723

EP - 6728

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 11

ER -

Alkali Counterions Impact Crystallization Kinetics of Apatite Nanocrystals from Amorphous Calcium Phosphate in Water at High pH

Abstract

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