Alcohol intake during pregnancy and timing of puberty in sons and daughters: a nationwide cohort study

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We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95% confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.

Original languageEnglish
JournalReproductive toxicology (Elmsford, N.Y.)
Pages (from-to)35-42
Number of pages8
Publication statusPublished - 2020

    Research areas

  • alcohol, maternal exposure, prenatal exposure delayed effects, puberty, menarche

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