Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study

Christian S Antoniussen; Cécile Proust-Lima; Daniel B Ibsen; Anja Olsen; Kim Overvad; Anne Tjønneland; Pietro Ferrari; Christina C Dahm

doi:10.1007/s10654-024-01179-5

Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study

Christian S Antoniussen, Cécile Proust-Lima, Daniel B Ibsen, Anja Olsen, Kim Overvad, Anne Tjønneland, Pietro Ferrari, Christina C Dahm^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Alcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50-65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 months and their average alcohol intake at the ages of 20, 30, 40, and 50 years. Alcohol consumption trajectories were estimated using latent class mixed models. BC cases were identified through record linkage to the Danish Cancer Registry. To examine associations between alcohol consumption trajectories and BC, we fitted a proportional hazard model adjusted for potential confounding factors using data from 24,543 postmenopausal women without missing covariate information. We identified 4 alcohol consumption trajectory profiles. During a median follow-up of 16.5 years, 1,591 cases of BC occurred. A mean alcohol consumption trajectory of > 10 g/day was associated with higher risk of BC (HR: 1.65, 95%CI: 1.35-2.03) compared to a mean alcohol consumption trajectory of < 6 g/day. We found no association between trajectory profiles characterized by lower alcohol intakes in early adulthood followed by increasing consumption of alcohol in adulthood compared to a consistently low intake of alcohol. Postmenopausal women drinking consistently high amounts of alcohol throughout adulthood had a higher risk of BC compared to women with a consistently low intake of alcohol.

Original language	English
Journal	European Journal of Epidemiology
Volume	39
Issue	12
Pages (from-to)	1353-1362
Number of pages	10
ISSN	0393-2990
DOIs	https://doi.org/10.1007/s10654-024-01179-5
Publication status	Published - Dec 2024

Keywords

Alcohol consumption
Breast cancer
Cancer
Diet
Health cohort
Latent class mixed models

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title = "Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study",

abstract = "Alcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50-65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 months and their average alcohol intake at the ages of 20, 30, 40, and 50 years. Alcohol consumption trajectories were estimated using latent class mixed models. BC cases were identified through record linkage to the Danish Cancer Registry. To examine associations between alcohol consumption trajectories and BC, we fitted a proportional hazard model adjusted for potential confounding factors using data from 24,543 postmenopausal women without missing covariate information. We identified 4 alcohol consumption trajectory profiles. During a median follow-up of 16.5 years, 1,591 cases of BC occurred. A mean alcohol consumption trajectory of > 10 g/day was associated with higher risk of BC (HR: 1.65, 95%CI: 1.35-2.03) compared to a mean alcohol consumption trajectory of < 6 g/day. We found no association between trajectory profiles characterized by lower alcohol intakes in early adulthood followed by increasing consumption of alcohol in adulthood compared to a consistently low intake of alcohol. Postmenopausal women drinking consistently high amounts of alcohol throughout adulthood had a higher risk of BC compared to women with a consistently low intake of alcohol.",

keywords = "Alcohol consumption, Breast cancer, Cancer, Diet, Health cohort, Latent class mixed models",

author = "Antoniussen, {Christian S} and C{\'e}cile Proust-Lima and Ibsen, {Daniel B} and Anja Olsen and Kim Overvad and Anne Tj{\o}nneland and Pietro Ferrari and Dahm, {Christina C}",

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doi = "10.1007/s10654-024-01179-5",

language = "English",

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Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study. / Antoniussen, Christian S; Proust-Lima, Cécile; Ibsen, Daniel B et al.
In: European Journal of Epidemiology, Vol. 39, No. 12, 12.2024, p. 1353-1362.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Alcohol consumption trajectories and risk of breast cancer among postmenopausal women

T2 - a Danish cohort study

AU - Antoniussen, Christian S

AU - Proust-Lima, Cécile

AU - Ibsen, Daniel B

AU - Olsen, Anja

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Ferrari, Pietro

AU - Dahm, Christina C

PY - 2024/12

Y1 - 2024/12

N2 - Alcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50-65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 months and their average alcohol intake at the ages of 20, 30, 40, and 50 years. Alcohol consumption trajectories were estimated using latent class mixed models. BC cases were identified through record linkage to the Danish Cancer Registry. To examine associations between alcohol consumption trajectories and BC, we fitted a proportional hazard model adjusted for potential confounding factors using data from 24,543 postmenopausal women without missing covariate information. We identified 4 alcohol consumption trajectory profiles. During a median follow-up of 16.5 years, 1,591 cases of BC occurred. A mean alcohol consumption trajectory of > 10 g/day was associated with higher risk of BC (HR: 1.65, 95%CI: 1.35-2.03) compared to a mean alcohol consumption trajectory of < 6 g/day. We found no association between trajectory profiles characterized by lower alcohol intakes in early adulthood followed by increasing consumption of alcohol in adulthood compared to a consistently low intake of alcohol. Postmenopausal women drinking consistently high amounts of alcohol throughout adulthood had a higher risk of BC compared to women with a consistently low intake of alcohol.

AB - Alcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50-65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 months and their average alcohol intake at the ages of 20, 30, 40, and 50 years. Alcohol consumption trajectories were estimated using latent class mixed models. BC cases were identified through record linkage to the Danish Cancer Registry. To examine associations between alcohol consumption trajectories and BC, we fitted a proportional hazard model adjusted for potential confounding factors using data from 24,543 postmenopausal women without missing covariate information. We identified 4 alcohol consumption trajectory profiles. During a median follow-up of 16.5 years, 1,591 cases of BC occurred. A mean alcohol consumption trajectory of > 10 g/day was associated with higher risk of BC (HR: 1.65, 95%CI: 1.35-2.03) compared to a mean alcohol consumption trajectory of < 6 g/day. We found no association between trajectory profiles characterized by lower alcohol intakes in early adulthood followed by increasing consumption of alcohol in adulthood compared to a consistently low intake of alcohol. Postmenopausal women drinking consistently high amounts of alcohol throughout adulthood had a higher risk of BC compared to women with a consistently low intake of alcohol.

KW - Alcohol consumption

KW - Breast cancer

KW - Cancer

KW - Diet

KW - Health cohort

KW - Latent class mixed models

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U2 - 10.1007/s10654-024-01179-5

DO - 10.1007/s10654-024-01179-5

M3 - Journal article

C2 - 39630402

SN - 0393-2990

VL - 39

SP - 1353

EP - 1362

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

IS - 12

ER -

Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study

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Keywords

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