Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

Vijay Walia, Adrian Cuenca, Melanie Vetter, Christine Insinna, Sumeth Perera, Quanlong Lu, Daniel A. Ritt, Elizabeth Semler, Suzanne Specht, Jimmy Stauffer, Deborah K. Morrison, Esben Lorentzen, Christopher J. Westlake*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

44 Citations (Scopus)

Abstract

Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.

Original languageEnglish
JournalDevelopmental Cell
Volume50
Issue2
Pages (from-to)229-246.e7
Number of pages18
ISSN1534-5807
DOIs
Publication statusPublished - 2019

Keywords

  • Akt
  • ciliogenesis
  • FIP3
  • LPA
  • lysophosphatidic acid
  • MC
  • mother centriole
  • phosphorylation
  • preciliary trafficking
  • Rab11 effector switch
  • Rabin8
  • WDR44

Fingerprint

Dive into the research topics of 'Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis'. Together they form a unique fingerprint.

Cite this