Abstract
Cilia assembly is inhibited by activation of the PI3K/Akt pathway by the serum factor lysophosphatidic acid, independent of cell cycle alterations. Walia et al. show that activated Akt phosphorylates WDR44, stabilizing its effector-based binding to Rab11 and preventing Rabin8 preciliary trafficking and ciliogenesis initiation.
Original language | English |
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Journal | Developmental Cell |
Volume | 50 |
Issue | 2 |
Pages (from-to) | 229-246.e7 |
Number of pages | 18 |
ISSN | 1534-5807 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Akt
- ciliogenesis
- FIP3
- LPA
- lysophosphatidic acid
- MC
- mother centriole
- phosphorylation
- preciliary trafficking
- Rab11 effector switch
- Rabin8
- WDR44