Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Ingrid N Kuiper, Department of Occupational Medicine, Haukeland University Hospital, N-5021, Bergen, Norway. ingrid.kuiper@gmail.com., Norway
  • Cecilie Svanes, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Electronic address: ane.johannessen@uib.no., Norway
  • Bryndis Benediktsdottir, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Iceland
  • Randi J Bertelsen, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., Norway
  • Lennart Bråbäck, Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden., Sweden
  • Shyamali C Dharmage, Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia., Australia
  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sweden
  • Christer Janson, Department of Medical Sciences, Respiratory-, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden., Sweden
  • Rain Jögi, Lung Clinic, Tartu University Hospital, Tartu, Estonia., Estonia
  • Andrei Malinovschi, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden., Sweden
  • Melanie Matheson, Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia., Australia
  • Jesús Martínez Moratalla, Servicio de Salud de Castilla, Servicio de Neumología del Complejo Hospitalario Univerisitario de Albacete, La Mancha, Albacete, Spain., Spain
  • Francisco Gómez Real, Department of Obstetrics and Gynecology, Haukeland, University Hospital, Bergen, Norway and., Norway
  • José Luis Sánchez-Ramos, Facultad de Enfermeria, University of Huelva, Huelva, Spain., Spain
  • Vivi Schlünssen
  • Signe Timm
  • Ane Johannessen, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Electronic address: ane.johannessen@uib.no., Norway

BACKGROUND: Self-report questionnaires are commonly used in epidemiology, but may be susceptible to misclassification, especially if answers are given on behalf of others, e.g. children or parents. The aim was to determine agreement and analyse predictors of disagreement in parents' reports of offspring asthma, and in offspring reports of parents' asthma.

METHODS: In the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study, 6752 offspring (age range 18-51 years) and their parents (age range 39-66 years) reported their own and each other's asthma status. Agreement between asthma reports from offspring and parents was determined by calculating sensitivity, specificity, positive and negative predictive value and Cohen's kappa. The participants' own answers regarding themselves were defined as the gold standard. To investigate predictors for disagreement logistic regression analyses were performed to obtain odds ratios (OR) with 95% confidence intervals (CI) for sex, smoking status, education, comorbidity and severity of asthma.

RESULTS: Agreement was good for parental report of offspring early onset asthma (< 10 years, Cohen's kappa 0.72) and moderate for offspring later onset asthma (Cohen's kappa 0.46). Specificity was 0.99 for both, and sensitivity was 0.68 and 0.36, respectively. For offspring report of maternal and paternal asthma the agreement was good (Cohen's kappa 0.69 and 0.68), specificity was 0.96 and 0.97, and sensitivity was 0.72 and 0.68, respectively. The positive predictive value (PPV) was lowest for offspring report of maternal asthma (0.75), and highest for parents' report of early onset asthma in the offspring (0.83). The negative predictive value (NPV) was high for all four groups (0.94-0.97). In multivariate analyses current smokers (OR = 1.46 [95% CI 1.05, 2.02]) and fathers (OR = 1.31 [95% CI 1.08, 1.59]) were more likely to report offspring asthma incorrectly. Offspring wheeze was associated with reporting parental asthma incorrectly (OR = 1.60 [95% CI 1.21, 2.11]), both under- and over reporting.

CONCLUSIONS: Asthma reports across generations show moderate to good agreement, making information from other generations a useful tool in the absence of direct reports.

Original languageEnglish
JournalBMC Pulmonary Medicine
Volume18
Issue1
Pages (from-to)122
Number of pages10
ISSN1471-2466
DOIs
Publication statusPublished - 27 Jul 2018

    Research areas

  • agreement, asthma, questionnaire, self-report, transgenerational, validation

See relations at Aarhus University Citationformats

ID: 140329578