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Aging and senescence of skin cells in culture

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Studying age-related changes in the physiology, biochemistry, and molecular biology of isolated skin cell populations in culture has greatly expanded the understanding of the fundamental aspects of skin aging. The three main cell types that have been studied extensively with respect to cellular aging in vitro are dermal fibroblasts, epidermal keratinocytes, and melanocytes. Serial subcultivation of normal diploid skin cells can be performed only a limited number of times, and the emerging senescent phenotype can be categorized into structural, physiological, biochemical, and molecular phenotypes, which can be used as biomarkers of cellular aging in vitro. The rate and phenotype of aging are different in different cell types. There are both common features and specific features of aging of skin fibroblasts, keratinocytes, melanocytes, and other cell types. A progressive accumulation of damage in all types of macromolecules is a universal feature of cellular aging in all cell types. A progressive failure of molecular maintenance and repair pathways is the ultimate cause of cellular aging in vitro and in vivo.
Original languageEnglish
Title of host publicationTextbook of Aging Skin
EditorsM.A. Farage, K.W. Miller, Maibach H.I.
Number of pages8
Publication year22 Sep 2015
Publication statusPublished - 22 Sep 2015

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