Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk: Results from the EPIC-InterAct study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Judith S Brand
  • ,
  • Yvonne T van der Schouw
  • ,
  • N Charlotte Onland-Moret
  • ,
  • Stephen J Sharp
  • ,
  • Ken K Ong
  • ,
  • Kay-Tee Khaw
  • ,
  • Eva Ardanaz
  • ,
  • Pilar Amiano
  • ,
  • Heiner Boeing
  • ,
  • Maria-Dolores Chirlaque
  • ,
  • Françoise Clavel-Chapelon
  • ,
  • Francesca L Crowe
  • ,
  • Blandine de Lauzon-Guillain
  • ,
  • Eric J Duell
  • ,
  • Guy Fagherazzi
  • ,
  • Paul W Franks
  • ,
  • Sara Grioni
  • ,
  • Leif C Groop
  • ,
  • Rudolf Kaaks
  • ,
  • Timothy J Key
  • ,
  • Peter M Nilsson
  • ,
  • Kim Overvad
  • Domenico Palli
  • ,
  • Salvatore Panico
  • ,
  • J Ramón Quirós
  • ,
  • Olov Rolandsson
  • ,
  • Carlotta Sacerdote
  • ,
  • María-José Sánchez
  • ,
  • Nadia Slimani
  • ,
  • Birgit Teucher
  • ,
  • Anne Tjonneland
  • ,
  • Rosario Tumino
  • ,
  • Daphne L van der A
  • ,
  • Edith J M Feskens
  • ,
  • Claudia Langenberg
  • ,
  • Nita G Forouhi
  • ,
  • Elio Riboli
  • ,
  • Nicholas J Wareham
  • ,
  • The InterAct Consortium
OBJECTIVEAge at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODSData were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTSMean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages 0.05).CONCLUSIONSEarly menopause is associated with a greater risk of type 2 diabetes.
Original languageEnglish
JournalDiabetes Care
Volume36
Issue4
Pages (from-to)1012-9
Number of pages8
ISSN0149-5992
DOIs
Publication statusPublished - Apr 2013

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