Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study

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Age at Menarche and Type 2 Diabetes Risk : The EPIC-InterAct study. / Elks, Cathy E; Ong, Ken K; Scott, Robert A; van der Schouw, Yvonne T; Brand, Judith S; Wark, Petra A; Amiano, Pilar; Balkau, Beverley; Barricarte, Aurelio; Boeing, Heiner; Fonseca-Nunes, Ana; Franks, Paul W; Grioni, Sara; Halkjaer, Jytte; Kaaks, Rudolf; Key, Timothy J; Khaw, Kay Tee; Mattiello, Amalia; Nilsson, Carl Martin Peter; Overvad, Kim; Palli, Domenico; Quirós, J Ramón; Rinaldi, Sabina; Rolandsson, Olov; Romieu, Isabelle; Sacerdote, Carlotta; Sánchez, María-José; Spijkerman, Annemieke M W; Tjonneland, Anne; Tormo, Maria-Jose; Tumino, Rosario; van der A, Daphne L; Forouhi, Nita G; Sharp, Stephen J; Langenberg, Claudia; Riboli, Elio; Wareham, Nicholas J; InterAct Consortium.

In: Diabetes Care, Vol. 36, No. 11, 11.2013, p. 3526-34.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Elks, CE, Ong, KK, Scott, RA, van der Schouw, YT, Brand, JS, Wark, PA, Amiano, P, Balkau, B, Barricarte, A, Boeing, H, Fonseca-Nunes, A, Franks, PW, Grioni, S, Halkjaer, J, Kaaks, R, Key, TJ, Khaw, KT, Mattiello, A, Nilsson, CMP, Overvad, K, Palli, D, Quirós, JR, Rinaldi, S, Rolandsson, O, Romieu, I, Sacerdote, C, Sánchez, M-J, Spijkerman, AMW, Tjonneland, A, Tormo, M-J, Tumino, R, van der A, DL, Forouhi, NG, Sharp, SJ, Langenberg, C, Riboli, E, Wareham, NJ & InterAct Consortium 2013, 'Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study', Diabetes Care, vol. 36, no. 11, pp. 3526-34. https://doi.org/10.2337/dc13-0446

APA

Elks, C. E., Ong, K. K., Scott, R. A., van der Schouw, Y. T., Brand, J. S., Wark, P. A., Amiano, P., Balkau, B., Barricarte, A., Boeing, H., Fonseca-Nunes, A., Franks, P. W., Grioni, S., Halkjaer, J., Kaaks, R., Key, T. J., Khaw, K. T., Mattiello, A., Nilsson, C. M. P., ... InterAct Consortium (2013). Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study. Diabetes Care, 36(11), 3526-34. https://doi.org/10.2337/dc13-0446

CBE

Elks CE, Ong KK, Scott RA, van der Schouw YT, Brand JS, Wark PA, Amiano P, Balkau B, Barricarte A, Boeing H, Fonseca-Nunes A, Franks PW, Grioni S, Halkjaer J, Kaaks R, Key TJ, Khaw KT, Mattiello A, Nilsson CMP, Overvad K, Palli D, Quirós JR, Rinaldi S, Rolandsson O, Romieu I, Sacerdote C, Sánchez M-J, Spijkerman AMW, Tjonneland A, Tormo M-J, Tumino R, van der A DL, Forouhi NG, Sharp SJ, Langenberg C, Riboli E, Wareham NJ, InterAct Consortium. 2013. Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study. Diabetes Care. 36(11):3526-34. https://doi.org/10.2337/dc13-0446

MLA

Vancouver

Elks CE, Ong KK, Scott RA, van der Schouw YT, Brand JS, Wark PA et al. Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study. Diabetes Care. 2013 Nov;36(11):3526-34. https://doi.org/10.2337/dc13-0446

Author

Elks, Cathy E ; Ong, Ken K ; Scott, Robert A ; van der Schouw, Yvonne T ; Brand, Judith S ; Wark, Petra A ; Amiano, Pilar ; Balkau, Beverley ; Barricarte, Aurelio ; Boeing, Heiner ; Fonseca-Nunes, Ana ; Franks, Paul W ; Grioni, Sara ; Halkjaer, Jytte ; Kaaks, Rudolf ; Key, Timothy J ; Khaw, Kay Tee ; Mattiello, Amalia ; Nilsson, Carl Martin Peter ; Overvad, Kim ; Palli, Domenico ; Quirós, J Ramón ; Rinaldi, Sabina ; Rolandsson, Olov ; Romieu, Isabelle ; Sacerdote, Carlotta ; Sánchez, María-José ; Spijkerman, Annemieke M W ; Tjonneland, Anne ; Tormo, Maria-Jose ; Tumino, Rosario ; van der A, Daphne L ; Forouhi, Nita G ; Sharp, Stephen J ; Langenberg, Claudia ; Riboli, Elio ; Wareham, Nicholas J ; InterAct Consortium. / Age at Menarche and Type 2 Diabetes Risk : The EPIC-InterAct study. In: Diabetes Care. 2013 ; Vol. 36, No. 11. pp. 3526-34.

Bibtex

@article{cb3edd9506cb44b8b3b5f80173e015ea,
title = "Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study",
abstract = "OBJECTIVE Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from 26 research centers across eight European countries. We tested the association between age at menarche and incident type 2 diabetes using Prentice-weighted Cox regression in 15,168 women (n = 5,995 cases). Models were adjusted in a sequential manner for potential confounding and mediating factors, including adult BMI. RESULTS Mean menarcheal age ranged from 12.6 to 13.6 years across InterAct countries. Each year later menarche was associated with 0.32 kg/m(2) lower adult BMI. Women in the earliest menarche quintile (8-11 years, n = 2,418) had 70% higher incidence of type 2 diabetes compared with those in the middle quintile (13 years, n = 3,634), adjusting for age at recruitment, research center, and a range of lifestyle and reproductive factors (hazard ratio [HR], 1.70; 95% CI, 1.49-1.94; P <0.001). Adjustment for BMI partially attenuated this association (HR, 1.42; 95% CI, 1.18-1.71; P <0.001). Later menarche beyond the median age was not protective against type 2 diabetes. CONCLUSIONS Women with history of early menarche have higher risk of type 2 diabetes in adulthood. Less than half of this association appears to be mediated by higher adult BMI, suggesting that early pubertal development also may directly increase type 2 diabetes risk.",
author = "Elks, {Cathy E} and Ong, {Ken K} and Scott, {Robert A} and {van der Schouw}, {Yvonne T} and Brand, {Judith S} and Wark, {Petra A} and Pilar Amiano and Beverley Balkau and Aurelio Barricarte and Heiner Boeing and Ana Fonseca-Nunes and Franks, {Paul W} and Sara Grioni and Jytte Halkjaer and Rudolf Kaaks and Key, {Timothy J} and Khaw, {Kay Tee} and Amalia Mattiello and Nilsson, {Carl Martin Peter} and Kim Overvad and Domenico Palli and Quir{\'o}s, {J Ram{\'o}n} and Sabina Rinaldi and Olov Rolandsson and Isabelle Romieu and Carlotta Sacerdote and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Spijkerman, {Annemieke M W} and Anne Tjonneland and Maria-Jose Tormo and Rosario Tumino and {van der A}, {Daphne L} and Forouhi, {Nita G} and Sharp, {Stephen J} and Claudia Langenberg and Elio Riboli and Wareham, {Nicholas J} and {InterAct Consortium}",
year = "2013",
month = nov,
doi = "10.2337/dc13-0446",
language = "English",
volume = "36",
pages = "3526--34",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "11",

}

RIS

TY - JOUR

T1 - Age at Menarche and Type 2 Diabetes Risk

T2 - The EPIC-InterAct study

AU - Elks, Cathy E

AU - Ong, Ken K

AU - Scott, Robert A

AU - van der Schouw, Yvonne T

AU - Brand, Judith S

AU - Wark, Petra A

AU - Amiano, Pilar

AU - Balkau, Beverley

AU - Barricarte, Aurelio

AU - Boeing, Heiner

AU - Fonseca-Nunes, Ana

AU - Franks, Paul W

AU - Grioni, Sara

AU - Halkjaer, Jytte

AU - Kaaks, Rudolf

AU - Key, Timothy J

AU - Khaw, Kay Tee

AU - Mattiello, Amalia

AU - Nilsson, Carl Martin Peter

AU - Overvad, Kim

AU - Palli, Domenico

AU - Quirós, J Ramón

AU - Rinaldi, Sabina

AU - Rolandsson, Olov

AU - Romieu, Isabelle

AU - Sacerdote, Carlotta

AU - Sánchez, María-José

AU - Spijkerman, Annemieke M W

AU - Tjonneland, Anne

AU - Tormo, Maria-Jose

AU - Tumino, Rosario

AU - van der A, Daphne L

AU - Forouhi, Nita G

AU - Sharp, Stephen J

AU - Langenberg, Claudia

AU - Riboli, Elio

AU - Wareham, Nicholas J

AU - InterAct Consortium

PY - 2013/11

Y1 - 2013/11

N2 - OBJECTIVE Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from 26 research centers across eight European countries. We tested the association between age at menarche and incident type 2 diabetes using Prentice-weighted Cox regression in 15,168 women (n = 5,995 cases). Models were adjusted in a sequential manner for potential confounding and mediating factors, including adult BMI. RESULTS Mean menarcheal age ranged from 12.6 to 13.6 years across InterAct countries. Each year later menarche was associated with 0.32 kg/m(2) lower adult BMI. Women in the earliest menarche quintile (8-11 years, n = 2,418) had 70% higher incidence of type 2 diabetes compared with those in the middle quintile (13 years, n = 3,634), adjusting for age at recruitment, research center, and a range of lifestyle and reproductive factors (hazard ratio [HR], 1.70; 95% CI, 1.49-1.94; P <0.001). Adjustment for BMI partially attenuated this association (HR, 1.42; 95% CI, 1.18-1.71; P <0.001). Later menarche beyond the median age was not protective against type 2 diabetes. CONCLUSIONS Women with history of early menarche have higher risk of type 2 diabetes in adulthood. Less than half of this association appears to be mediated by higher adult BMI, suggesting that early pubertal development also may directly increase type 2 diabetes risk.

AB - OBJECTIVE Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from 26 research centers across eight European countries. We tested the association between age at menarche and incident type 2 diabetes using Prentice-weighted Cox regression in 15,168 women (n = 5,995 cases). Models were adjusted in a sequential manner for potential confounding and mediating factors, including adult BMI. RESULTS Mean menarcheal age ranged from 12.6 to 13.6 years across InterAct countries. Each year later menarche was associated with 0.32 kg/m(2) lower adult BMI. Women in the earliest menarche quintile (8-11 years, n = 2,418) had 70% higher incidence of type 2 diabetes compared with those in the middle quintile (13 years, n = 3,634), adjusting for age at recruitment, research center, and a range of lifestyle and reproductive factors (hazard ratio [HR], 1.70; 95% CI, 1.49-1.94; P <0.001). Adjustment for BMI partially attenuated this association (HR, 1.42; 95% CI, 1.18-1.71; P <0.001). Later menarche beyond the median age was not protective against type 2 diabetes. CONCLUSIONS Women with history of early menarche have higher risk of type 2 diabetes in adulthood. Less than half of this association appears to be mediated by higher adult BMI, suggesting that early pubertal development also may directly increase type 2 diabetes risk.

U2 - 10.2337/dc13-0446

DO - 10.2337/dc13-0446

M3 - Journal article

C2 - 24159179

VL - 36

SP - 3526

EP - 3534

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 11

ER -