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Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort

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Age at Menarche and Risk of Multiple Sclerosis : A Prospective Cohort Study Based on the Danish National Birth Cohort. / Nielsen, Nete Munk; Harpsoe, Maria; Simonsen, Jacob; Stenager, Egon; Magyari, Melinda; Koch-Henriksen, Nils; Baker, Jennifer L.; Hjalgrim, Henrik; Frisch, Morten; Bager, Peter.

In: American Journal of Epidemiology, Vol. 185, No. 8, 15.04.2017, p. 712-719.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nielsen, NM, Harpsoe, M, Simonsen, J, Stenager, E, Magyari, M, Koch-Henriksen, N, Baker, JL, Hjalgrim, H, Frisch, M & Bager, P 2017, 'Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort', American Journal of Epidemiology, vol. 185, no. 8, pp. 712-719. https://doi.org/10.1093/aje/kww160

APA

Nielsen, N. M., Harpsoe, M., Simonsen, J., Stenager, E., Magyari, M., Koch-Henriksen, N., Baker, J. L., Hjalgrim, H., Frisch, M., & Bager, P. (2017). Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort. American Journal of Epidemiology, 185(8), 712-719. https://doi.org/10.1093/aje/kww160

CBE

Nielsen NM, Harpsoe M, Simonsen J, Stenager E, Magyari M, Koch-Henriksen N, Baker JL, Hjalgrim H, Frisch M, Bager P. 2017. Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort. American Journal of Epidemiology. 185(8):712-719. https://doi.org/10.1093/aje/kww160

MLA

Vancouver

Nielsen NM, Harpsoe M, Simonsen J, Stenager E, Magyari M, Koch-Henriksen N et al. Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort. American Journal of Epidemiology. 2017 Apr 15;185(8):712-719. https://doi.org/10.1093/aje/kww160

Author

Nielsen, Nete Munk ; Harpsoe, Maria ; Simonsen, Jacob ; Stenager, Egon ; Magyari, Melinda ; Koch-Henriksen, Nils ; Baker, Jennifer L. ; Hjalgrim, Henrik ; Frisch, Morten ; Bager, Peter. / Age at Menarche and Risk of Multiple Sclerosis : A Prospective Cohort Study Based on the Danish National Birth Cohort. In: American Journal of Epidemiology. 2017 ; Vol. 185, No. 8. pp. 712-719.

Bibtex

@article{812a962a27a841f09c33b94d44e8c76d,
title = "Age at Menarche and Risk of Multiple Sclerosis: A Prospective Cohort Study Based on the Danish National Birth Cohort",
abstract = "Few studies have addressed the possible association between age at menarche and multiple sclerosis ( MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% ( hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.",
keywords = "cohort studies, Danish National Birth Cohort, menarcheal age, multiple sclerosis, INCREASING INCIDENCE, ALL-CAUSE, WOMEN, CHILDHOOD, PREGNANCY, PUBERTY, CHILDREN, METAANALYSIS, ADOLESCENCE, REGISTER",
author = "Nielsen, {Nete Munk} and Maria Harpsoe and Jacob Simonsen and Egon Stenager and Melinda Magyari and Nils Koch-Henriksen and Baker, {Jennifer L.} and Henrik Hjalgrim and Morten Frisch and Peter Bager",
year = "2017",
month = apr,
day = "15",
doi = "10.1093/aje/kww160",
language = "English",
volume = "185",
pages = "712--719",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Age at Menarche and Risk of Multiple Sclerosis

T2 - A Prospective Cohort Study Based on the Danish National Birth Cohort

AU - Nielsen, Nete Munk

AU - Harpsoe, Maria

AU - Simonsen, Jacob

AU - Stenager, Egon

AU - Magyari, Melinda

AU - Koch-Henriksen, Nils

AU - Baker, Jennifer L.

AU - Hjalgrim, Henrik

AU - Frisch, Morten

AU - Bager, Peter

PY - 2017/4/15

Y1 - 2017/4/15

N2 - Few studies have addressed the possible association between age at menarche and multiple sclerosis ( MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% ( hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.

AB - Few studies have addressed the possible association between age at menarche and multiple sclerosis ( MS), and results are conflicting. We studied this issue in a large prospective cohort study. The study cohort comprised 77,330 women included in the Danish National Birth Cohort (1996-2002). Information on menarcheal age was ascertained at the first interview, which took place in the 16th week of pregnancy. Women were followed for MS from the first interview to December 31, 2011. Associations between age at menarche and risk of MS were evaluated with hazard ratios and 95% confidence intervals using Cox proportional hazards regression models. Overall, 226 women developed MS during an average follow-up period of 11.7 years. Age at menarche among women with MS was generally lower than that among women without MS (Wilcoxon rank-sum test; P = 0.002). We observed an inverse association between age at menarche and MS risk. For each 1-year increase in age at menarche, risk of MS was reduced by 13% ( hazard ratio = 0.87, 95% confidence interval: 0.79, 0.96). Early age at menarche appears to be associated with an increased risk of MS. The mechanisms behind this association remain to be established.

KW - cohort studies

KW - Danish National Birth Cohort

KW - menarcheal age

KW - multiple sclerosis

KW - INCREASING INCIDENCE

KW - ALL-CAUSE

KW - WOMEN

KW - CHILDHOOD

KW - PREGNANCY

KW - PUBERTY

KW - CHILDREN

KW - METAANALYSIS

KW - ADOLESCENCE

KW - REGISTER

U2 - 10.1093/aje/kww160

DO - 10.1093/aje/kww160

M3 - Journal article

C2 - 28369233

VL - 185

SP - 712

EP - 719

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 8

ER -