Affective lability in parents with schizophrenia or bipolar disorder and their co-parents - The Danish High Risk and Resilience Study VIA 7

Nanna Lawaetz Steffensen, Nicoline Hemager, Anette Faurskov Bundgaard, Ditte Lou Gantriis, Birgitte Klee Burton, Ditte Ellersgaard, Anders Helles Carlsen, Vibeke Bliksted, Kerstin J. Plessen, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Anne A.E. Thorup, Ole Mors, Aja Neergaard Greve*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

In bipolar disorder, dysregulation of affect is a core feature while knowledge on affective lability in schizophrenia is sparse. Research on affective lability in partners to individuals with schizophrenia or bipolar disorder is also lacking. The objective of this study was to investigate affective lability in parents with schizophrenia or bipolar disorder, and their co-parents without these disorders. The Danish High Risk and Resilience Study – VIA 7 is a population-based cohort study. This study focuses on parents diagnosed with schizophrenia (n = 148), their co-parents (n = 157), parents with bipolar disorder (n = 98), their co-parents (n = 89) and control parents (n = 359). The Affective Lability Scale – short form (ALS-SF) was used to measure affective lability. We found significantly higher levels of affective lability in parents with schizophrenia and bipolar disorder compared with controls, but no significant differences between bipolar disorder and schizophrenia. Co-parents to parents with schizophrenia had significantly higher levels of affective lability compared to controls. Our results add to the existing knowledge concerning underlying transdiagnostic factors and nonrandom mating in schizophrenia and bipolar disorder and highlight the need for studies of parental affective lability as a potential risk factor for offspring in families with parental schizophrenia or bipolar disorder.

Original languageEnglish
Article number115092
JournalPsychiatry Research
Volume321
Number of pages6
ISSN0165-1781
DOIs
Publication statusPublished - Mar 2023

Keywords

  • Assortative mating
  • Bipolar disorder
  • Mental disorders
  • Nonrandom mating
  • Parents
  • Schizophrenia

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