Advances in targeted delivery of small interfering RNA using simple bioconjugates

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Standard

Advances in targeted delivery of small interfering RNA using simple bioconjugates. / Nielsen, Christoffer; Kjems, Jørgen; Sorensen, Kristine Rothaus; Engelholm, Lars Henning; Behrendt, Niels.

In: Expert Opinion on Drug Delivery, Vol. 11, No. 5, 01.01.2014, p. 791-822.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Harvard

Nielsen, C, Kjems, J, Sorensen, KR, Engelholm, LH & Behrendt, N 2014, 'Advances in targeted delivery of small interfering RNA using simple bioconjugates', Expert Opinion on Drug Delivery, vol. 11, no. 5, pp. 791-822. https://doi.org/10.1517/17425247.2014.896898

APA

Nielsen, C., Kjems, J., Sorensen, K. R., Engelholm, L. H., & Behrendt, N. (2014). Advances in targeted delivery of small interfering RNA using simple bioconjugates. Expert Opinion on Drug Delivery, 11(5), 791-822. https://doi.org/10.1517/17425247.2014.896898

CBE

Nielsen C, Kjems J, Sorensen KR, Engelholm LH, Behrendt N. 2014. Advances in targeted delivery of small interfering RNA using simple bioconjugates. Expert Opinion on Drug Delivery. 11(5):791-822. https://doi.org/10.1517/17425247.2014.896898

MLA

Nielsen, Christoffer et al. "Advances in targeted delivery of small interfering RNA using simple bioconjugates". Expert Opinion on Drug Delivery. 2014, 11(5). 791-822. https://doi.org/10.1517/17425247.2014.896898

Vancouver

Nielsen C, Kjems J, Sorensen KR, Engelholm LH, Behrendt N. Advances in targeted delivery of small interfering RNA using simple bioconjugates. Expert Opinion on Drug Delivery. 2014 Jan 1;11(5):791-822. https://doi.org/10.1517/17425247.2014.896898

Author

Nielsen, Christoffer ; Kjems, Jørgen ; Sorensen, Kristine Rothaus ; Engelholm, Lars Henning ; Behrendt, Niels. / Advances in targeted delivery of small interfering RNA using simple bioconjugates. In: Expert Opinion on Drug Delivery. 2014 ; Vol. 11, No. 5. pp. 791-822.

Bibtex

@article{208653f2f66f486c8bdf405fe5e1f586,
title = "Advances in targeted delivery of small interfering RNA using simple bioconjugates",
abstract = "Introduction: Development of drugs based on RNA interference by small interfering RNA (siRNA) has been progressing slowly due to a number of challenges associated with the in vivo behavior of siRNA. A central problem is controlling siRNA delivery to specific cell types. Here, we review existing literature on one type of strategy for solving the issue of cell-specific delivery of siRNA, namely delivering the siRNA as part of simple bioconjugate constructs. Areas covered: This review presents current experience from strategies aimed at targeting siRNA to specific cell types, by associating the siRNA with a targeting moiety, in a simple bioconjugate construct. We discuss the use of different types of targeting moieties, as well as the different conjugation strategies employed for preparing these bioconjugate constructs that deliver the siRNA to target cells. We focus especially on the in-built or passive functionalities associated with each strategy, in order to identify key elements of successful siRNA delivery strategies with potential for further exploration. Expert opinion: By evaluating the current literature on this subject, we identify strategies and concepts that are suitable for future studies, to enable the development of highly efficient simple bioconjugates for targeted siRNA delivery with therapeutic application.",
keywords = "Bioconjugation, Clinical trials, Intracellular routing of small interfering RNA, RNA interference, Small interfering RNA, Small interfering RNA bioconjugates, Small interfering RNA stability, Targeted delivery",
author = "Christoffer Nielsen and J{\o}rgen Kjems and Sorensen, {Kristine Rothaus} and Engelholm, {Lars Henning} and Niels Behrendt",
year = "2014",
month = "1",
day = "1",
doi = "10.1517/17425247.2014.896898",
language = "English",
volume = "11",
pages = "791--822",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Taylor & francis",
number = "5",

}

RIS

TY - JOUR

T1 - Advances in targeted delivery of small interfering RNA using simple bioconjugates

AU - Nielsen, Christoffer

AU - Kjems, Jørgen

AU - Sorensen, Kristine Rothaus

AU - Engelholm, Lars Henning

AU - Behrendt, Niels

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Introduction: Development of drugs based on RNA interference by small interfering RNA (siRNA) has been progressing slowly due to a number of challenges associated with the in vivo behavior of siRNA. A central problem is controlling siRNA delivery to specific cell types. Here, we review existing literature on one type of strategy for solving the issue of cell-specific delivery of siRNA, namely delivering the siRNA as part of simple bioconjugate constructs. Areas covered: This review presents current experience from strategies aimed at targeting siRNA to specific cell types, by associating the siRNA with a targeting moiety, in a simple bioconjugate construct. We discuss the use of different types of targeting moieties, as well as the different conjugation strategies employed for preparing these bioconjugate constructs that deliver the siRNA to target cells. We focus especially on the in-built or passive functionalities associated with each strategy, in order to identify key elements of successful siRNA delivery strategies with potential for further exploration. Expert opinion: By evaluating the current literature on this subject, we identify strategies and concepts that are suitable for future studies, to enable the development of highly efficient simple bioconjugates for targeted siRNA delivery with therapeutic application.

AB - Introduction: Development of drugs based on RNA interference by small interfering RNA (siRNA) has been progressing slowly due to a number of challenges associated with the in vivo behavior of siRNA. A central problem is controlling siRNA delivery to specific cell types. Here, we review existing literature on one type of strategy for solving the issue of cell-specific delivery of siRNA, namely delivering the siRNA as part of simple bioconjugate constructs. Areas covered: This review presents current experience from strategies aimed at targeting siRNA to specific cell types, by associating the siRNA with a targeting moiety, in a simple bioconjugate construct. We discuss the use of different types of targeting moieties, as well as the different conjugation strategies employed for preparing these bioconjugate constructs that deliver the siRNA to target cells. We focus especially on the in-built or passive functionalities associated with each strategy, in order to identify key elements of successful siRNA delivery strategies with potential for further exploration. Expert opinion: By evaluating the current literature on this subject, we identify strategies and concepts that are suitable for future studies, to enable the development of highly efficient simple bioconjugates for targeted siRNA delivery with therapeutic application.

KW - Bioconjugation

KW - Clinical trials

KW - Intracellular routing of small interfering RNA

KW - RNA interference

KW - Small interfering RNA

KW - Small interfering RNA bioconjugates

KW - Small interfering RNA stability

KW - Targeted delivery

U2 - 10.1517/17425247.2014.896898

DO - 10.1517/17425247.2014.896898

M3 - Review

VL - 11

SP - 791

EP - 822

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 5

ER -