Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output

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Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish : Insight into central and peripheral determinants of cardiac output. / Joyce, William; Egginton, Stuart; Farrell, Anthony P.; Axelsson, Michael.

In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Vol. 230, 2019, p. 28-38.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Joyce, W, Egginton, S, Farrell, AP & Axelsson, M 2019, 'Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output', Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, vol. 230, pp. 28-38. https://doi.org/10.1016/j.cbpa.2018.12.012

APA

Joyce, W., Egginton, S., Farrell, A. P., & Axelsson, M. (2019). Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 230, 28-38. https://doi.org/10.1016/j.cbpa.2018.12.012

CBE

Joyce W, Egginton S, Farrell AP, Axelsson M. 2019. Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 230:28-38. https://doi.org/10.1016/j.cbpa.2018.12.012

MLA

Vancouver

Joyce W, Egginton S, Farrell AP, Axelsson M. Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2019;230:28-38. https://doi.org/10.1016/j.cbpa.2018.12.012

Author

Joyce, William ; Egginton, Stuart ; Farrell, Anthony P. ; Axelsson, Michael. / Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish : Insight into central and peripheral determinants of cardiac output. In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2019 ; Vol. 230. pp. 28-38.

Bibtex

@article{cd285c4d302745a0bebc5d1ef850bde9,
title = "Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish: Insight into central and peripheral determinants of cardiac output",
abstract = "Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒ H ), adrenaline (5 nmol kg −1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (G sys ). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg −1 ) generated a large increase in Q̇ by increasing G sys , a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart.",
keywords = "Adenosine, Adrenaline, Channichthyidae, Conductance, Heart rate",
author = "William Joyce and Stuart Egginton and Farrell, {Anthony P.} and Michael Axelsson",
year = "2019",
doi = "10.1016/j.cbpa.2018.12.012",
language = "English",
volume = "230",
pages = "28--38",
journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",
issn = "1095-6433",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish

T2 - Insight into central and peripheral determinants of cardiac output

AU - Joyce, William

AU - Egginton, Stuart

AU - Farrell, Anthony P.

AU - Axelsson, Michael

PY - 2019

Y1 - 2019

N2 - Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒ H ), adrenaline (5 nmol kg −1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (G sys ). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg −1 ) generated a large increase in Q̇ by increasing G sys , a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart.

AB - Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒ H ), adrenaline (5 nmol kg −1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (G sys ). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg −1 ) generated a large increase in Q̇ by increasing G sys , a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart.

KW - Adenosine

KW - Adrenaline

KW - Channichthyidae

KW - Conductance

KW - Heart rate

UR - http://www.scopus.com/inward/record.url?scp=85059345699&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2018.12.012

DO - 10.1016/j.cbpa.2018.12.012

M3 - Journal article

C2 - 30594528

AN - SCOPUS:85059345699

VL - 230

SP - 28

EP - 38

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

SN - 1095-6433

ER -