Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study

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Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study. / Aleksandrova, Krasimira; Drogan, Dagmar; Boeing, Heiner; Jenab, Mazda; Bueno-de-Mesquita, H Bas; Jansen, Eugene; van Duijnhoven, Fränzel J B; Rinaldi, Sabina; Fedirko, Veronika; Romieu, Isabelle; Kaaks, Rudolf; Riboli, Elio; Gunter, Marc J; Romaguera, Dora; Westhpal, Sabine; Overvad, Kim; Tjønneland, Anne; Halkjaer, Jytte; Boutronruault, Mariechristine; Clavel-Chapelon, Françoise; Lukanova, Annekatrin; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Vidalis, Pavlos; Panico, Salvatore; Agnoli, Claudia; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Buckland, Genevieve; Sánchez-Cruz, José-Juan; Dorronsoro, Miren; Díaz, María José Tormo; Barricarte, Aurelio; Quiros, J Ramon; Peeters, Petra H; May, Anne; Hallmans, Göran; Palmqvist, Richard; Crowe, Francesca L; Khaw, Kay-Tee; Wareham, Nickolas; Pischon, Tobias.

In: International Journal of Cancer, Vol. 134, No. 3, 01.02.2014, p. 612-21.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Aleksandrova, K, Drogan, D, Boeing, H, Jenab, M, Bueno-de-Mesquita, HB, Jansen, E, van Duijnhoven, FJB, Rinaldi, S, Fedirko, V, Romieu, I, Kaaks, R, Riboli, E, Gunter, MJ, Romaguera, D, Westhpal, S, Overvad, K, Tjønneland, A, Halkjaer, J, Boutronruault, M, Clavel-Chapelon, F, Lukanova, A, Trichopoulou, A, Trichopoulos, D, Vidalis, P, Panico, S, Agnoli, C, Palli, D, Tumino, R, Vineis, P, Buckland, G, Sánchez-Cruz, J-J, Dorronsoro, M, Díaz, MJT, Barricarte, A, Quiros, JR, Peeters, PH, May, A, Hallmans, G, Palmqvist, R, Crowe, FL, Khaw, K-T, Wareham, N & Pischon, T 2014, 'Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study', International Journal of Cancer, vol. 134, no. 3, pp. 612-21. https://doi.org/10.1002/ijc.28368

APA

Aleksandrova, K., Drogan, D., Boeing, H., Jenab, M., Bueno-de-Mesquita, H. B., Jansen, E., van Duijnhoven, F. J. B., Rinaldi, S., Fedirko, V., Romieu, I., Kaaks, R., Riboli, E., Gunter, M. J., Romaguera, D., Westhpal, S., Overvad, K., Tjønneland, A., Halkjaer, J., Boutronruault, M., ... Pischon, T. (2014). Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study. International Journal of Cancer, 134(3), 612-21. https://doi.org/10.1002/ijc.28368

CBE

Aleksandrova K, Drogan D, Boeing H, Jenab M, Bueno-de-Mesquita HB, Jansen E, van Duijnhoven FJB, Rinaldi S, Fedirko V, Romieu I, Kaaks R, Riboli E, Gunter MJ, Romaguera D, Westhpal S, Overvad K, Tjønneland A, Halkjaer J, Boutronruault M, Clavel-Chapelon F, Lukanova A, Trichopoulou A, Trichopoulos D, Vidalis P, Panico S, Agnoli C, Palli D, Tumino R, Vineis P, Buckland G, Sánchez-Cruz J-J, Dorronsoro M, Díaz MJT, Barricarte A, Quiros JR, Peeters PH, May A, Hallmans G, Palmqvist R, Crowe FL, Khaw K-T, Wareham N, Pischon T. 2014. Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study. International Journal of Cancer. 134(3):612-21. https://doi.org/10.1002/ijc.28368

MLA

Vancouver

Aleksandrova K, Drogan D, Boeing H, Jenab M, Bueno-de-Mesquita HB, Jansen E et al. Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study. International Journal of Cancer. 2014 Feb 1;134(3):612-21. https://doi.org/10.1002/ijc.28368

Author

Aleksandrova, Krasimira ; Drogan, Dagmar ; Boeing, Heiner ; Jenab, Mazda ; Bueno-de-Mesquita, H Bas ; Jansen, Eugene ; van Duijnhoven, Fränzel J B ; Rinaldi, Sabina ; Fedirko, Veronika ; Romieu, Isabelle ; Kaaks, Rudolf ; Riboli, Elio ; Gunter, Marc J ; Romaguera, Dora ; Westhpal, Sabine ; Overvad, Kim ; Tjønneland, Anne ; Halkjaer, Jytte ; Boutronruault, Mariechristine ; Clavel-Chapelon, Françoise ; Lukanova, Annekatrin ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Vidalis, Pavlos ; Panico, Salvatore ; Agnoli, Claudia ; Palli, Domenico ; Tumino, Rosario ; Vineis, Paolo ; Buckland, Genevieve ; Sánchez-Cruz, José-Juan ; Dorronsoro, Miren ; Díaz, María José Tormo ; Barricarte, Aurelio ; Quiros, J Ramon ; Peeters, Petra H ; May, Anne ; Hallmans, Göran ; Palmqvist, Richard ; Crowe, Francesca L ; Khaw, Kay-Tee ; Wareham, Nickolas ; Pischon, Tobias. / Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study. In: International Journal of Cancer. 2014 ; Vol. 134, No. 3. pp. 612-21.

Bibtex

@article{27b88efe23b342daa4bf541216004411,
title = "Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study",
abstract = "Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which eleven biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analysed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk-sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CI-s were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs bottom tertile RR 1.68, 95% CI 1.06 - 2.65; Ptrend = 0.02) and in women (RR 1.67, 95% CI 1.09 - 2.56; Ptrend = 0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37 to 57%) of the association in men and 50% (95% CI 40 to 65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggests that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk. {\textcopyright} 2013 Wiley Periodicals, Inc.",
author = "Krasimira Aleksandrova and Dagmar Drogan and Heiner Boeing and Mazda Jenab and Bueno-de-Mesquita, {H Bas} and Eugene Jansen and {van Duijnhoven}, {Fr{\"a}nzel J B} and Sabina Rinaldi and Veronika Fedirko and Isabelle Romieu and Rudolf Kaaks and Elio Riboli and Gunter, {Marc J} and Dora Romaguera and Sabine Westhpal and Kim Overvad and Anne Tj{\o}nneland and Jytte Halkjaer and Mariechristine Boutronruault and Fran{\c c}oise Clavel-Chapelon and Annekatrin Lukanova and Antonia Trichopoulou and Dimitrios Trichopoulos and Pavlos Vidalis and Salvatore Panico and Claudia Agnoli and Domenico Palli and Rosario Tumino and Paolo Vineis and Genevieve Buckland and Jos{\'e}-Juan S{\'a}nchez-Cruz and Miren Dorronsoro and D{\'i}az, {Mar{\'i}a Jos{\'e} Tormo} and Aurelio Barricarte and Quiros, {J Ramon} and Peeters, {Petra H} and Anne May and G{\"o}ran Hallmans and Richard Palmqvist and Crowe, {Francesca L} and Kay-Tee Khaw and Nickolas Wareham and Tobias Pischon",
note = "Copyright {\textcopyright} 2013 UICC.",
year = "2014",
month = feb,
day = "1",
doi = "10.1002/ijc.28368",
language = "English",
volume = "134",
pages = "612--21",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "JohnWiley & Sons, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Adiposity, mediating biomarkers and risk of colon cancer in the european prospective investigation into cancer and nutrition study

AU - Aleksandrova, Krasimira

AU - Drogan, Dagmar

AU - Boeing, Heiner

AU - Jenab, Mazda

AU - Bueno-de-Mesquita, H Bas

AU - Jansen, Eugene

AU - van Duijnhoven, Fränzel J B

AU - Rinaldi, Sabina

AU - Fedirko, Veronika

AU - Romieu, Isabelle

AU - Kaaks, Rudolf

AU - Riboli, Elio

AU - Gunter, Marc J

AU - Romaguera, Dora

AU - Westhpal, Sabine

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Halkjaer, Jytte

AU - Boutronruault, Mariechristine

AU - Clavel-Chapelon, Françoise

AU - Lukanova, Annekatrin

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Vidalis, Pavlos

AU - Panico, Salvatore

AU - Agnoli, Claudia

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Buckland, Genevieve

AU - Sánchez-Cruz, José-Juan

AU - Dorronsoro, Miren

AU - Díaz, María José Tormo

AU - Barricarte, Aurelio

AU - Quiros, J Ramon

AU - Peeters, Petra H

AU - May, Anne

AU - Hallmans, Göran

AU - Palmqvist, Richard

AU - Crowe, Francesca L

AU - Khaw, Kay-Tee

AU - Wareham, Nickolas

AU - Pischon, Tobias

N1 - Copyright © 2013 UICC.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which eleven biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analysed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk-sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CI-s were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs bottom tertile RR 1.68, 95% CI 1.06 - 2.65; Ptrend = 0.02) and in women (RR 1.67, 95% CI 1.09 - 2.56; Ptrend = 0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37 to 57%) of the association in men and 50% (95% CI 40 to 65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggests that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk. © 2013 Wiley Periodicals, Inc.

AB - Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which eleven biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analysed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk-sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CI-s were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs bottom tertile RR 1.68, 95% CI 1.06 - 2.65; Ptrend = 0.02) and in women (RR 1.67, 95% CI 1.09 - 2.56; Ptrend = 0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37 to 57%) of the association in men and 50% (95% CI 40 to 65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggests that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk. © 2013 Wiley Periodicals, Inc.

U2 - 10.1002/ijc.28368

DO - 10.1002/ijc.28368

M3 - Journal article

C2 - 23824948

VL - 134

SP - 612

EP - 621

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -