Adipose Tissue Lipophilic Index and Risk of Ischemic Stroke-A Danish Case-Cohort Study

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DOI

  • Linda Tram, Department of Cardiology, Aalborg University Hospital, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark. linda.tram@rn.dk., Denmark
  • Stine Krogh Venø, Department of Clinical Medicine, Aalborg University, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark. s.venoe@rn.dk., Denmark
  • Christina Catherine Dahm
  • Birthe H Thomsen, Department of Cardiology, Aalborg University Hospital, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark. bht@rn.dk., Denmark
  • Martin Berg Johansen, Unit of Clinical Biostatistics, Aalborg University Hospital, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark. martin.johansen@rn.dk.
  • ,
  • Kim Overvad
  • Erik Berg Schmidt, Department of Clinical Medicine, Aalborg University, Hobrovej 18⁻22, DK-9100 Aalborg, Denmark. ebs@rn.dk., Aalborg University

Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemic stroke and its subtypes. A case-cohort study was conducted based on the Danish cohort study Diet, Cancer, and Health, which includes 57,053 subjects aged 50⁻64 years at enrolment. A subcohort (n = 3500) was randomly drawn from the whole cohort. All ischemic stroke cases were validated and categorized into subtypes. The lipophilic index was calculated based on fatty acid profiles in adipose tissue. Subjects were divided into quintiles and a weighted Cox proportional hazards regression model was used to calculate hazard ratios. After appropriate exclusions, a subcohort of 3194 subjects and 1752 cases of ischemic stroke were included. When comparing the fifth quintile of the lipophilic index with the first quintile, the hazard ratio for ischemic stroke was 0.92 (95% confidence interval 0.75, 1.13) and the trend across quintiles was not statistically significant (p = 0.1727). In conclusion, no association was found between the lipophilic index and ischemic stroke or its subtypes.

Original languageEnglish
JournalNutrients
Volume10
Issue11
Pages (from-to)1570
Number of pages11
ISSN2072-6643
DOIs
Publication statusPublished - 23 Oct 2018

    Research areas

  • adipose tissue, cardiovascular disease, case-cohort, cell membrane fluidity, fatty acids, ischemic stroke, lipophilic index, melting points

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