Adipose tissue content of alpha-linolenic acid and development of peripheral artery disease: a Danish case-cohort study

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  • Christian S Bork, Department of Cardiology, Aalborg University Hospital, Søndre Skovvej 15, 9000, Aalborg, Denmark. c.bork@rn.dk., Denmark
  • Anne N Lasota, Aalborg University, Denmark
  • Søren Lundbye-Christensen, Aalborg University
  • ,
  • Marianne U Jakobsen, Division for Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet 2, 2800, Kgs. Lyngby, Denmark.
  • ,
  • Anne Tjønneland, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Denmark
  • Kim Overvad
  • Erik B Schmidt, Aalborg University

PURPOSE: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD).

METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established between 1993 and 1997. Potential PAD cases were identified using linkage with The Danish National Patient Register and all potential cases were validated. Adipose tissue samples from the buttock were collected at baseline and fatty acid composition was determined in cases and in a random sample (n = 3500) from the cohort by gas chromatography. Statistical analyses were performed using weighted Cox regression allowing for different baseline hazards among sexes.

RESULTS: During a median of 13.5 years of follow-up, we identified 863 PAD cases with complete information. The median adipose tissue content of ALA in the sub-cohort (n = 3197) was 0.84% (interquartile range 0.73-0.94%) of total fatty acids. In multivariate analyses including adjustment for established risk factors, we observed a U-shaped association between ALA in adipose tissue and rate of PAD, but the association was not statistically significant (P = 0.131). Similar pattern of associations were observed between ALA content in adipose tissue and the rate of PAD among men and women.

CONCLUSIONS: We found indications of a U-shaped association between adipose tissue content of ALA and the rate of PAD, but the association was not statistically significant.

Original languageEnglish
JournalEuropean Journal of Nutrition
Volume59
Issue7
Pages (from-to)3191-3200
Number of pages10
ISSN1436-6207
DOIs
Publication statusPublished - 2020

    Research areas

  • adipose tissue, alpha-linolenic acid, case-cohort study, peripheral artery disease, n-3 fatty acids

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