Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Christian Stevns Hansen, Steno Diabetes Center Copenhagen, Niels Steensens Vej 2-4, 2820, Gentofte, Denmark. christian.stevns.hansen@regionh.dk., Denmark
  • Dorte Vistisen, Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark. Electronic address: kristine.faerch@regionh.dk., Denmark
  • Marit Eika Jørgensen, Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, DK-2820, Gentofte, Denmark. Electronic address: kristine.faerch@regionh.dk.
  • ,
  • Daniel R Witte
  • Eric J Brunner, Department of Epidemiology and Public Health, University College London, United Kingdom
  • Adam G Tabák, First Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary., Department of Epidemiology and Public Health, University College London, United Kingdom
  • Mika Kivimäki, Department of Epidemiology and Public Health, University College London, United Kingdom
  • Michael Roden, Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • Marek Malik, National Heart and Lung Institute, Imperial College London, United Kingdom
  • Christian Herder, German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf

BACKGROUND: Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations of biomarkers of subclinical inflammation and adiponectin with subsequent changes in heart rate (HR) and heart rate variability (HRV) in non-diabetic and diabetic individuals.

METHODS: Data are based on up to 25,050 person-examinations for 8469 study participants of the Whitehall II cohort study. Measures of CAN included HR and several HRV indices. Associations between baseline serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-1 receptor antagonist (IL-1Ra) and adiponectin and 5-year changes in HR and six HRV indices were estimated using mixed-effects models adjusting for age, sex, ethnicity, body mass index (BMI), metabolic covariates and medication. A modifying effect of diabetes was tested.

RESULTS: Higher levels of IL-1Ra were associated with higher increases in HR. Additional associations with measures of HRV were observed for hsCRP, IL-6 and IL-1Ra, but these associations were explained by BMI and other confounders. Associations between adiponectin, HR and HRV differed depending on diabetes status. Higher adiponectin levels were associated with more pronounced decreases in HR and increases in three measures of HRV reflecting both sympathetic and vagal activity, but these findings were limited to individuals with type 2 diabetes.

CONCLUSIONS: Higher IL-1Ra levels appeared as novel risk marker for increases in HR. Higher adiponectin levels were associated with a more favourable development of cardiovascular autonomic function in individuals with type 2 diabetes independently of multiple confounders.

Original languageEnglish
JournalCardiovascular Diabetology
Volume16
Issue1
Pages (from-to)153
Number of pages9
ISSN1475-2840
DOIs
Publication statusPublished - 1 Dec 2017

    Research areas

  • Journal Article

See relations at Aarhus University Citationformats

ID: 121292132