Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

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  • Laure Dossus, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., France
  • Silvia Franceschi, Infections Section, International Agency for Research on Cancer, Lyon, France., France
  • Carine Biessy, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., France
  • Anne-Sophie Navionis, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., France
  • Ruth C Travis, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., United Kingdom
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland., Finland
  • Augustin Scalbert, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., France
  • Isabelle Romieu, Adjunct professor, Hubert Department of Global Health, Emory University, Atlanta, Georgia 30322, USA., United States
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Denmark
  • Anja Olsen
  • Kim Overvad
  • Marie-Christine Boutron-Ruault, 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France., France
  • Fabrice Bonnet, CHU Rennes, Rennes 1 University, Rennes, France., France
  • Agnès Fournier, 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Paris-Sud University, UMRS 1018, F-94805 Villejuif, France [3] Institut Gustave Roussy, F-94805 Villejuif, France., France
  • Renee T Fortner, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Germany
  • Rudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Germany
  • Krasimira Aleksandrova, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany., Germany
  • Antonia Trichopoulou, Hellenic Health Foundation, Athens, Greece., Greece
  • Carlo La Vecchia, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy., Italy
  • Eleni Peppa, Hellenic Health Foundation, Athens, Greece., Greece
  • Rosario Tumino, Civic-M.P. Arezzo Hospital, Italy
  • Salvatore Panico, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Federico II University, Naples, Italy., Italy
  • Domenico Palli, Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy., Italy
  • Claudia Agnoli, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, Milano, Italy., Italy
  • Paolo Vineis, Italian Institute for Genomic Medicine (IIGM/HuGeF), Torino, Italy., Italy
  • Bas Bueno-de-Mesquita, Academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, 50603, Kuala Lumpur, Malaysia., Malaysia
  • Petra H Peeters, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands., Netherlands
  • Guri Skeie, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø - The Arctic University of Norway, Tromsø, Norway., Norway
  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spain
  • María-Dolores Chirlaque, Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain., Spain
  • Eva Ardanaz, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Spain
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain., Spain
  • Jose Ramón Quirós, Public Health Directorate, Asturias, Spain., Spain
  • Miren Dorronsoro, Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain., Spain
  • Maria Sandström, Center for Cancer Prevention (CPO-Piemonte), Turin, Italy, Department of Radiation Sciences, Oncology Umeå University, 901 85 Umeå, Sweden., Sweden
  • Lena Maria Nilsson, 1] Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, Umeå 901 85, Sweden [2] Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, 1A, 9 tr, Kirurgcentrum, 952, Umeå 901 85, Sweden., Sweden
  • Julie A Schmidt, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., United Kingdom
  • Kay-Tee Khaw, University of Cambridge, United Kingdom
  • Konstantinos K Tsilidis, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ionnina 45110, Greece., Greece
  • Dagfinn Aune, Bjørknes University College, Oslo, Norway., Norway
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, United Kingdom
  • Sabina Rinaldi, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France., France

Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin(IL)-6, IL-10 and TNF-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 =0.69, 95%CI: 0.49-0.98, Ptrend =0.04) but not among men (ORT3vs.T1 =1.36, 95%CI: 0.67-2.76, Ptrend =0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 =1.59, 95%CI: 1.13-2.25, Ptrend =0.01) but not in men (ORT3vs.T1 =1.78, 95%CI: 0.80-3.98, Ptrend =0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalInternational Journal of Cancer
Volume142
Issue7
Pages (from-to)1332-1342
Number of pages11
ISSN0020-7136
DOIs
Publication statusPublished - 1 Apr 2018

    Research areas

  • Journal Article, adipokine, cytokine, inflammation, prospective cohort, thyroid cancer

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