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Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host

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Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. / Salmon, Didier; Vanwalleghem, Gilles; Morias, Yannick et al.

In: Science, Vol. 337, No. 6093, 27.07.2012, p. 463-466.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Salmon, D, Vanwalleghem, G, Morias, Y, Denoeud, J, Krumbholz, C, Lhommé, F, Bachmaier, S, Kador, M, Gossmann, J, Dias, FBS, De Muylder, G, Uzureau, P, Magez, S, Moser, M, De Baetselier, P, Van Den Abbeele, J, Beschin, A, Boshart, M & Pays, E 2012, 'Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host', Science, vol. 337, no. 6093, pp. 463-466. https://doi.org/10.1126/science.1222753

APA

Salmon, D., Vanwalleghem, G., Morias, Y., Denoeud, J., Krumbholz, C., Lhommé, F., Bachmaier, S., Kador, M., Gossmann, J., Dias, F. B. S., De Muylder, G., Uzureau, P., Magez, S., Moser, M., De Baetselier, P., Van Den Abbeele, J., Beschin, A., Boshart, M., & Pays, E. (2012). Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science, 337(6093), 463-466. https://doi.org/10.1126/science.1222753

CBE

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FBS, et al. 2012. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science. 337(6093):463-466. https://doi.org/10.1126/science.1222753

MLA

Salmon, Didier et al. "Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host". Science. 2012, 337(6093). 463-466. https://doi.org/10.1126/science.1222753

Vancouver

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F et al. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science. 2012 Jul 27;337(6093):463-466. doi: 10.1126/science.1222753

Author

Salmon, Didier ; Vanwalleghem, Gilles ; Morias, Yannick et al. / Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. In: Science. 2012 ; Vol. 337, No. 6093. pp. 463-466.

Bibtex

@article{825c488a69374c0eae30a775f812df56,
title = "Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host",
abstract = "The parasite Trypanosoma brucei possesses a large family of transmembrane receptor-like adenylate cyclases. Activation of these enzymes requires the dimerization of the catalytic domain and typically occurs under stress. Using a dominant-negative strategy, we found that reducing adenylate cyclase activity by about 50% allowed trypanosome growth but reduced the parasite's ability to control the early innate immune defense of the host. Specifically, activation of trypanosome adenylate cyclase resulting from parasite phagocytosis by liver myeloid cells inhibited the synthesis of the trypanosome-controlling cytokine tumor necrosis factor-α through activation of protein kinase A in these cells. Thus, adenylate cyclase activity of lyzed trypanosomes favors early host colonization by live parasites. The role of adenylate cyclases at the host-parasite interface could explain the expansion and polymorphism of this gene family.",
author = "Didier Salmon and Gilles Vanwalleghem and Yannick Morias and Julie Denoeud and Carsten Krumbholz and Fr{\'e}d{\'e}ric Lhomm{\'e} and Sabine Bachmaier and Markus Kador and Jasmin Gossmann and Dias, {Fernando Braga Stehling} and {De Muylder}, G{\'e}raldine and Pierrick Uzureau and Stefan Magez and Muriel Moser and {De Baetselier}, Patrick and {Van Den Abbeele}, Jan and Alain Beschin and Michael Boshart and Etienne Pays",
year = "2012",
month = jul,
day = "27",
doi = "10.1126/science.1222753",
language = "English",
volume = "337",
pages = "463--466",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6093",

}

RIS

TY - JOUR

T1 - Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host

AU - Salmon, Didier

AU - Vanwalleghem, Gilles

AU - Morias, Yannick

AU - Denoeud, Julie

AU - Krumbholz, Carsten

AU - Lhommé, Frédéric

AU - Bachmaier, Sabine

AU - Kador, Markus

AU - Gossmann, Jasmin

AU - Dias, Fernando Braga Stehling

AU - De Muylder, Géraldine

AU - Uzureau, Pierrick

AU - Magez, Stefan

AU - Moser, Muriel

AU - De Baetselier, Patrick

AU - Van Den Abbeele, Jan

AU - Beschin, Alain

AU - Boshart, Michael

AU - Pays, Etienne

PY - 2012/7/27

Y1 - 2012/7/27

N2 - The parasite Trypanosoma brucei possesses a large family of transmembrane receptor-like adenylate cyclases. Activation of these enzymes requires the dimerization of the catalytic domain and typically occurs under stress. Using a dominant-negative strategy, we found that reducing adenylate cyclase activity by about 50% allowed trypanosome growth but reduced the parasite's ability to control the early innate immune defense of the host. Specifically, activation of trypanosome adenylate cyclase resulting from parasite phagocytosis by liver myeloid cells inhibited the synthesis of the trypanosome-controlling cytokine tumor necrosis factor-α through activation of protein kinase A in these cells. Thus, adenylate cyclase activity of lyzed trypanosomes favors early host colonization by live parasites. The role of adenylate cyclases at the host-parasite interface could explain the expansion and polymorphism of this gene family.

AB - The parasite Trypanosoma brucei possesses a large family of transmembrane receptor-like adenylate cyclases. Activation of these enzymes requires the dimerization of the catalytic domain and typically occurs under stress. Using a dominant-negative strategy, we found that reducing adenylate cyclase activity by about 50% allowed trypanosome growth but reduced the parasite's ability to control the early innate immune defense of the host. Specifically, activation of trypanosome adenylate cyclase resulting from parasite phagocytosis by liver myeloid cells inhibited the synthesis of the trypanosome-controlling cytokine tumor necrosis factor-α through activation of protein kinase A in these cells. Thus, adenylate cyclase activity of lyzed trypanosomes favors early host colonization by live parasites. The role of adenylate cyclases at the host-parasite interface could explain the expansion and polymorphism of this gene family.

UR - http://www.scopus.com/inward/record.url?scp=84864344932&partnerID=8YFLogxK

U2 - 10.1126/science.1222753

DO - 10.1126/science.1222753

M3 - Journal article

AN - SCOPUS:84864344932

VL - 337

SP - 463

EP - 466

JO - Science

JF - Science

SN - 0036-8075

IS - 6093

ER -