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Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging

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Standard

Acute reperfusion without recanalization : Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. / Makris, Nikolaos; Chamard, Leila; Mikkelsen, Irene K; Hermier, Marc; Derex, Laurent; Pedraza, Salvador; Thomalla, Götz; Østergaard, Leif; Baron, Jean-Claude; Nighoghossian, Norbert; Berthezène, Yves; Cho, Tae-Hee.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 39, No. 2, 02.2019, p. 251-259.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Makris, N, Chamard, L, Mikkelsen, IK, Hermier, M, Derex, L, Pedraza, S, Thomalla, G, Østergaard, L, Baron, J-C, Nighoghossian, N, Berthezène, Y & Cho, T-H 2019, 'Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 2, pp. 251-259. https://doi.org/10.1177/0271678X17744716

APA

Makris, N., Chamard, L., Mikkelsen, I. K., Hermier, M., Derex, L., Pedraza, S., ... Cho, T-H. (2019). Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 39(2), 251-259. https://doi.org/10.1177/0271678X17744716

CBE

Makris N, Chamard L, Mikkelsen IK, Hermier M, Derex L, Pedraza S, Thomalla G, Østergaard L, Baron J-C, Nighoghossian N, Berthezène Y, Cho T-H. 2019. Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism. 39(2):251-259. https://doi.org/10.1177/0271678X17744716

MLA

Vancouver

Makris N, Chamard L, Mikkelsen IK, Hermier M, Derex L, Pedraza S et al. Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism. 2019 Feb;39(2):251-259. https://doi.org/10.1177/0271678X17744716

Author

Makris, Nikolaos ; Chamard, Leila ; Mikkelsen, Irene K ; Hermier, Marc ; Derex, Laurent ; Pedraza, Salvador ; Thomalla, Götz ; Østergaard, Leif ; Baron, Jean-Claude ; Nighoghossian, Norbert ; Berthezène, Yves ; Cho, Tae-Hee. / Acute reperfusion without recanalization : Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging. In: Journal of Cerebral Blood Flow and Metabolism. 2019 ; Vol. 39, No. 2. pp. 251-259.

Bibtex

@article{b232ad5f4f164aa5ab843c68f2509e05,
title = "Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging",
abstract = "Acute reperfusion despite persistent arterial occlusion may occur in up to 30{\%} of ischemic stroke patients. Recruitment of leptomeningeal collaterals may explain this phenomenon. Using dynamic susceptibility-contrast perfusion imaging (DSC-PI), we assessed acute changes in collateral flow among patients without recanalization. From a multicenter prospective database (I-KNOW), 46 patients with magnetic resonance angiography visible occlusion in whom both reperfusion and recanalization were assessed within 6 h of onset were identified. Maps of collateral flow at arterial, capillary and late venous phases were generated from DSC-PI through inter-frame registration, baseline signal subtraction and temporal summation, and graded blind to all other relevant clinical and radiological data using the Higashida scale. Flow direction and the acute evolution of collaterals were evaluated against the reperfusion status. Among patients without recanalization ( n = 33), flow direction remained retrograde. Collateral grades significantly improved between admission and acute follow-up in patients who reperfused (OR: 4.57; 95{\%} CI: 1.1-22.7; p = 0.048), but not in those without reperfusion (OR: 1.34; 95{\%} CI: 0.4-4.5; p = 0.623). Our study confirmed that acute reperfusion without recanalization is associated with a significant improvement of retrograde collateral flow. DSC-PI can detect acute changes in collateral flow, and may help evaluate novel treatments targeting leptomeningeal collaterals.",
keywords = "Collateral circulation, ischemic stroke, magnetic resonance imaging, recanalization, reperfusion",
author = "Nikolaos Makris and Leila Chamard and Mikkelsen, {Irene K} and Marc Hermier and Laurent Derex and Salvador Pedraza and G{\"o}tz Thomalla and Leif {\O}stergaard and Jean-Claude Baron and Norbert Nighoghossian and Yves Berthez{\`e}ne and Tae-Hee Cho",
year = "2019",
month = "2",
doi = "10.1177/0271678X17744716",
language = "English",
volume = "39",
pages = "251--259",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Acute reperfusion without recanalization

T2 - Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging

AU - Makris, Nikolaos

AU - Chamard, Leila

AU - Mikkelsen, Irene K

AU - Hermier, Marc

AU - Derex, Laurent

AU - Pedraza, Salvador

AU - Thomalla, Götz

AU - Østergaard, Leif

AU - Baron, Jean-Claude

AU - Nighoghossian, Norbert

AU - Berthezène, Yves

AU - Cho, Tae-Hee

PY - 2019/2

Y1 - 2019/2

N2 - Acute reperfusion despite persistent arterial occlusion may occur in up to 30% of ischemic stroke patients. Recruitment of leptomeningeal collaterals may explain this phenomenon. Using dynamic susceptibility-contrast perfusion imaging (DSC-PI), we assessed acute changes in collateral flow among patients without recanalization. From a multicenter prospective database (I-KNOW), 46 patients with magnetic resonance angiography visible occlusion in whom both reperfusion and recanalization were assessed within 6 h of onset were identified. Maps of collateral flow at arterial, capillary and late venous phases were generated from DSC-PI through inter-frame registration, baseline signal subtraction and temporal summation, and graded blind to all other relevant clinical and radiological data using the Higashida scale. Flow direction and the acute evolution of collaterals were evaluated against the reperfusion status. Among patients without recanalization ( n = 33), flow direction remained retrograde. Collateral grades significantly improved between admission and acute follow-up in patients who reperfused (OR: 4.57; 95% CI: 1.1-22.7; p = 0.048), but not in those without reperfusion (OR: 1.34; 95% CI: 0.4-4.5; p = 0.623). Our study confirmed that acute reperfusion without recanalization is associated with a significant improvement of retrograde collateral flow. DSC-PI can detect acute changes in collateral flow, and may help evaluate novel treatments targeting leptomeningeal collaterals.

AB - Acute reperfusion despite persistent arterial occlusion may occur in up to 30% of ischemic stroke patients. Recruitment of leptomeningeal collaterals may explain this phenomenon. Using dynamic susceptibility-contrast perfusion imaging (DSC-PI), we assessed acute changes in collateral flow among patients without recanalization. From a multicenter prospective database (I-KNOW), 46 patients with magnetic resonance angiography visible occlusion in whom both reperfusion and recanalization were assessed within 6 h of onset were identified. Maps of collateral flow at arterial, capillary and late venous phases were generated from DSC-PI through inter-frame registration, baseline signal subtraction and temporal summation, and graded blind to all other relevant clinical and radiological data using the Higashida scale. Flow direction and the acute evolution of collaterals were evaluated against the reperfusion status. Among patients without recanalization ( n = 33), flow direction remained retrograde. Collateral grades significantly improved between admission and acute follow-up in patients who reperfused (OR: 4.57; 95% CI: 1.1-22.7; p = 0.048), but not in those without reperfusion (OR: 1.34; 95% CI: 0.4-4.5; p = 0.623). Our study confirmed that acute reperfusion without recanalization is associated with a significant improvement of retrograde collateral flow. DSC-PI can detect acute changes in collateral flow, and may help evaluate novel treatments targeting leptomeningeal collaterals.

KW - Collateral circulation

KW - ischemic stroke

KW - magnetic resonance imaging

KW - recanalization

KW - reperfusion

U2 - 10.1177/0271678X17744716

DO - 10.1177/0271678X17744716

M3 - Journal article

VL - 39

SP - 251

EP - 259

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 2

ER -