Acute kidney injury in a child treated with cisplatin and amphotericin B

Torjus Skajaa; Mia Faerch; Henrik Hasle

doi:10.1007/s00280-024-04705-0

Acute kidney injury in a child treated with cisplatin and amphotericin B

Torjus Skajaa^*, Mia Faerch, Henrik Hasle

^*Corresponding author for this work

Department of Clinical Medicine - Department of Paediatrics

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the combination of Liposomal amphotericin B and cisplatin in an adolescent with osteosarcoma. Acute kidney injury (peak creatinine 431 µmol/L) consistent with drug-induced acute tubulointerstitial nephritis was observed a few days after concomitant administration of cisplatin and amphotericin B. Kidney function nearly normalised during follow-up. The timing of the concomitant administration of amphotericin B and cisplatin led us to presume that the combination was the cause of renal failure, and we conclude that concurrent administration of cisplatin and amphotericin B should be avoided.

Original language	English
Journal	Cancer Chemotherapy and Pharmacology
Volume	94
Issue	4
Pages (from-to)	623-626
Number of pages	4
ISSN	0344-5704
DOIs	https://doi.org/10.1007/s00280-024-04705-0
Publication status	Published - Oct 2024

Keywords

Acute kidney injury
Amphotericin B
Cisplatin
Nephrotoxicity
Osteosarcoma
Paediatric Osteosarcoma

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10.1007/s00280-024-04705-0

Acute kidney injury in a child treated with cisplatin and amphotericin BFinal published version, 592 KBLicence: CC BY

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title = "Acute kidney injury in a child treated with cisplatin and amphotericin B",

abstract = "Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the combination of Liposomal amphotericin B and cisplatin in an adolescent with osteosarcoma. Acute kidney injury (peak creatinine 431 µmol/L) consistent with drug-induced acute tubulointerstitial nephritis was observed a few days after concomitant administration of cisplatin and amphotericin B. Kidney function nearly normalised during follow-up. The timing of the concomitant administration of amphotericin B and cisplatin led us to presume that the combination was the cause of renal failure, and we conclude that concurrent administration of cisplatin and amphotericin B should be avoided.",

keywords = "Acute kidney injury, Amphotericin B, Cisplatin, Nephrotoxicity, Osteosarcoma, Paediatric Osteosarcoma",

author = "Torjus Skajaa and Mia Faerch and Henrik Hasle",

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doi = "10.1007/s00280-024-04705-0",

language = "English",

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T1 - Acute kidney injury in a child treated with cisplatin and amphotericin B

AU - Skajaa, Torjus

AU - Faerch, Mia

AU - Hasle, Henrik

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/10

Y1 - 2024/10

N2 - Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the combination of Liposomal amphotericin B and cisplatin in an adolescent with osteosarcoma. Acute kidney injury (peak creatinine 431 µmol/L) consistent with drug-induced acute tubulointerstitial nephritis was observed a few days after concomitant administration of cisplatin and amphotericin B. Kidney function nearly normalised during follow-up. The timing of the concomitant administration of amphotericin B and cisplatin led us to presume that the combination was the cause of renal failure, and we conclude that concurrent administration of cisplatin and amphotericin B should be avoided.

AB - Cisplatin and amphotericin B are both known to be potentially nephrotoxic. We describe acute kidney injury due to the combination of Liposomal amphotericin B and cisplatin in an adolescent with osteosarcoma. Acute kidney injury (peak creatinine 431 µmol/L) consistent with drug-induced acute tubulointerstitial nephritis was observed a few days after concomitant administration of cisplatin and amphotericin B. Kidney function nearly normalised during follow-up. The timing of the concomitant administration of amphotericin B and cisplatin led us to presume that the combination was the cause of renal failure, and we conclude that concurrent administration of cisplatin and amphotericin B should be avoided.

KW - Acute kidney injury

KW - Amphotericin B

KW - Cisplatin

KW - Nephrotoxicity

KW - Osteosarcoma

KW - Paediatric Osteosarcoma

UR - https://www.scopus.com/pages/publications/85200568998

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DO - 10.1007/s00280-024-04705-0

M3 - Journal article

C2 - 39110201

AN - SCOPUS:85200568998

SN - 0344-5704

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SP - 623

EP - 626

JO - Cancer Chemotherapy and Pharmacology

JF - Cancer Chemotherapy and Pharmacology

IS - 4

ER -

Acute kidney injury in a child treated with cisplatin and amphotericin B

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