Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Anaesthesiology
  • Medical Research Laboratory
  • Anæstesiologisk Afdeling, SKS
  • Institute of Biostatistics
  • Centre for Clinical Pharmacology
  • The Department of Endocrinology and Diabetes
Intensive insulin therapy in critically ill patients reduces morbidity and mortality. The current study elucidates whether acute hyperinsulinemia per se could attenuate the systemic cytokine response and improve neutrophil function during endotoxin (lipopolysaccharide)-induced systemic inflammation in a porcine model.
Original languageEnglish
JournalAnesthesiology
Volume100
Issue4
Pages (from-to)861-70
Number of pages10
ISSN0003-3022
Publication statusPublished - 1 Apr 2004

    Research areas

  • Acute Disease, Animals, Blood Glucose, Blood Pressure, Endotoxins, Fatty Acids, Nonesterified, Female, Glucagon, Hyperinsulinism, Interleukin-6, Neutrophils, Swine, Systemic Inflammatory Response Syndrome, Tumor Necrosis Factor-alpha

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