Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics

Karin Rosenkilde Laursen; Berit Brøndum Rasmussen; Bernadette Rosati; Vibeke Heitmann Gutzke; Kirsten Østergaard; Peter Ravn; Søren Kenneth Kjærgaard; Merete Bilde; Marianne Glasius; Torben Sigsgaard

doi:10.1111/ina.12902

Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics

Karin Rosenkilde Laursen^*, Berit Brøndum Rasmussen, Bernadette Rosati, Vibeke Heitmann Gutzke, Kirsten Østergaard, Peter Ravn, Søren Kenneth Kjærgaard, Merete Bilde, Marianne Glasius, Torben Sigsgaard

^*Corresponding author for this work

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13 Citations (Scopus)

Abstract

Particulate matter is linked to adverse health effects, however, little is known about health effects of particles emitted from typical indoor sources. We examined acute health effects of short-term exposure to emissions from cooking and candles among asthmatics. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions lasting 5 h: (a) air mixed with emissions from cooking (fine particle mass concentration): (PM_2.5: 96.1 μg/m³), (b) air mixed with emissions from candles (PM_2.5: 89.8 μg/m³), and c) clean filtered air (PM_2.5: 5.8 μg/m³). Health effects (spirometry, fractional exhaled Nitric Oxide [FeNO], nasal volume and self-reported symptoms) were evaluated before exposure start, then 5 and 24 h after. During exposures volatile organic compounds (VOCs), particle size distributions, number concentrations and optical properties were measured. Generally, no statistically significant changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. The results indicate that emissions from cooking and candles exert mild inflammation in asthmatic males and decrease comfort among asthmatic males and females.

Original language	English
Journal	Indoor Air
Volume	31
Issue	6
Pages (from-to)	1993-2007
Number of pages	15
ISSN	0905-6947
DOIs	https://doi.org/10.1111/ina.12902
Publication status	Published - Nov 2021

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10.1111/ina.12902

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@article{7c07159719a34e0a94af8922a1699228,

title = "Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics",

abstract = "Particulate matter is linked to adverse health effects, however, little is known about health effects of particles emitted from typical indoor sources. We examined acute health effects of short-term exposure to emissions from cooking and candles among asthmatics. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions lasting 5 h: (a) air mixed with emissions from cooking (fine particle mass concentration): (PM2.5: 96.1 μg/m3), (b) air mixed with emissions from candles (PM2.5: 89.8 μg/m3), and c) clean filtered air (PM2.5: 5.8 μg/m3). Health effects (spirometry, fractional exhaled Nitric Oxide [FeNO], nasal volume and self-reported symptoms) were evaluated before exposure start, then 5 and 24 h after. During exposures volatile organic compounds (VOCs), particle size distributions, number concentrations and optical properties were measured. Generally, no statistically significant changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. The results indicate that emissions from cooking and candles exert mild inflammation in asthmatic males and decrease comfort among asthmatic males and females.",

keywords = "Indeklima, Helbredseffekter, Stegeos, Stearinlys, Velbefindende, Ultrafine partikler",

author = "Laursen, {Karin Rosenkilde} and Rasmussen, {Berit Br{\o}ndum} and Bernadette Rosati and Gutzke, {Vibeke Heitmann} and Kirsten {\O}stergaard and Peter Ravn and Kj{\ae}rgaard, {S{\o}ren Kenneth} and Merete Bilde and Marianne Glasius and Torben Sigsgaard",

year = "2021",

month = nov,

doi = "10.1111/ina.12902",

language = "English",

volume = "31",

pages = "1993--2007",

journal = "Indoor Air",

issn = "0905-6947",

publisher = "John Wiley and Sons Inc",

number = "6",

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Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics. / Laursen, Karin Rosenkilde; Rasmussen, Berit Brøndum; Rosati, Bernadette et al.
In: Indoor Air, Vol. 31, No. 6, 11.2021, p. 1993-2007.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics

AU - Laursen, Karin Rosenkilde

AU - Rasmussen, Berit Brøndum

AU - Rosati, Bernadette

AU - Gutzke, Vibeke Heitmann

AU - Østergaard, Kirsten

AU - Ravn, Peter

AU - Kjærgaard, Søren Kenneth

AU - Bilde, Merete

AU - Glasius, Marianne

AU - Sigsgaard, Torben

PY - 2021/11

Y1 - 2021/11

N2 - Particulate matter is linked to adverse health effects, however, little is known about health effects of particles emitted from typical indoor sources. We examined acute health effects of short-term exposure to emissions from cooking and candles among asthmatics. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions lasting 5 h: (a) air mixed with emissions from cooking (fine particle mass concentration): (PM2.5: 96.1 μg/m3), (b) air mixed with emissions from candles (PM2.5: 89.8 μg/m3), and c) clean filtered air (PM2.5: 5.8 μg/m3). Health effects (spirometry, fractional exhaled Nitric Oxide [FeNO], nasal volume and self-reported symptoms) were evaluated before exposure start, then 5 and 24 h after. During exposures volatile organic compounds (VOCs), particle size distributions, number concentrations and optical properties were measured. Generally, no statistically significant changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. The results indicate that emissions from cooking and candles exert mild inflammation in asthmatic males and decrease comfort among asthmatic males and females.

AB - Particulate matter is linked to adverse health effects, however, little is known about health effects of particles emitted from typical indoor sources. We examined acute health effects of short-term exposure to emissions from cooking and candles among asthmatics. In a randomized controlled double-blinded crossover study, 36 young non-smoking asthmatics attended three exposure sessions lasting 5 h: (a) air mixed with emissions from cooking (fine particle mass concentration): (PM2.5: 96.1 μg/m3), (b) air mixed with emissions from candles (PM2.5: 89.8 μg/m3), and c) clean filtered air (PM2.5: 5.8 μg/m3). Health effects (spirometry, fractional exhaled Nitric Oxide [FeNO], nasal volume and self-reported symptoms) were evaluated before exposure start, then 5 and 24 h after. During exposures volatile organic compounds (VOCs), particle size distributions, number concentrations and optical properties were measured. Generally, no statistically significant changes were observed in spirometry, FeNO, or nasal volume comparing cooking and candle exposures to clean air. In males, nasal volume and FeNO decreased after exposure to cooking and candles, respectively. Participants reported additional and more pronounced symptoms during exposure to cooking and candles compared to clean air. The results indicate that emissions from cooking and candles exert mild inflammation in asthmatic males and decrease comfort among asthmatic males and females.

KW - Indeklima

KW - Helbredseffekter

KW - Stegeos

KW - Stearinlys

KW - Velbefindende

KW - Ultrafine partikler

UR - http://www.scopus.com/inward/record.url?scp=85109369005&partnerID=8YFLogxK

U2 - 10.1111/ina.12902

DO - 10.1111/ina.12902

M3 - Journal article

C2 - 34235780

AN - SCOPUS:85109369005

SN - 0905-6947

VL - 31

SP - 1993

EP - 2007

JO - Indoor Air

JF - Indoor Air

IS - 6

ER -

Acute health effects from exposure to indoor ultrafine particles—A randomized controlled crossover study among young mild asthmatics

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