Acute endovascular reperfusion treatment in patients with ischaemic stroke and large-vessel occlusion (Denmark 2011–2017)

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DOI

  • Thomas Truelsen, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark
  • ,
  • Klaus Hansen, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark
  • ,
  • Grethe Andersen
  • Leif Sørensen
  • Charlotte Madsen, Department of Regional Health Research, University of Southern Denmark, Odense C, Denmark/The Multiple Sclerosis Clinic of Southern Jutland (Sønderborg, Kolding, Esbjerg), Department of Neurology, Sygehus Sønderjylland, Sønderborg, Denmark.
  • ,
  • Anabel Diaz, Department of Neuroradiology, University of Southern Denmark, Odense, Denmark.
  • ,
  • Trine Stavngaard, Department of Neuroradiology, Copenhagen University Hospital, Rigshospitalet, Denmark.
  • ,
  • Heidi H Hundborg, The Danish Clinical Quality Program (RKKP), National Clinical Registries, Aarhus, Denmark.
  • ,
  • Joan Højgaard, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark
  • ,
  • Niels Hjort
  • Helle K Iversen, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Denmark
  • ,
  • Søren P Johnsen, Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University and Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Claus Z Simonsen

BACKGROUND: Acute endovascular reperfusion treatment (aERT) of stroke patients with large vessel occlusions (LVO) is efficacious and safe according to several clinical trials. Data on outcome and safety of aERT in daily clinical routine is warranted, and in this study we present national data from Denmark 2011 -2017.

METHODS: National data for Denmark from 2011 through 2017 on all aERT procedures in patients with acute ischemic stroke and CTA/MRA verified LVO. Data were derived from the Danish Stroke Registry (DRS), a national clinical quality registry to which reporting is mandatory for all hospitals treating stroke patients. Outcome (mRS) after 3 months, including time of death, was assessed prospectively based on clinical examination or the Danish Civil Registration System (DCRS).

RESULTS: During the 7 years of observation a total of 1,720 patients were treated with aERT. The annual number of procedures increased from 128 in 2011 to 409 in 2017. The median age was 68 years, 58% were males, and median NIHSS at baseline was 16. Median time from symptoms onset to groin puncture was 238 minutes with a decreasing trend during the years. Successful recanalisation was reported in 1,306 (76%) of patients. At 3-months follow-up mRS 0-2 was reported in 46% whereas 14% of patients had died.

CONCLUSIONS: Routine data on aERT in acute ischemic stroke in Denmark from 2011-17 suggest that the procedure is safe and efficacious. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalEuropean Journal of Neurology
Volume26
Issue8
Pages (from-to)1044-1050
Number of pages7
ISSN1351-5101
DOIs
Publication statusPublished - 2019

    Research areas

  • cerebral circulation, cerebrovascular disease, endovascular procedures, epidemiology, management, neurologic disorders, research methods, stroke

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