Biomechanical factors have long been associated with the initiation and development of atherosclerosis. However, this research has primarily been focused on the importance of Wall Shear Stress (WSS), which has been shown to be low or oscillating in areas prone to the development of atherosclerotic plaques.1 The emergence of finite element solvers capable of coupling different physics has allowed further investigations into the initiation of atherosclerosis. In this abstract, we present a novel method for coupling mechanical deformations of endothelial cells to the mass transport of lipid through tight junctions.