Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine

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Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. / Ribeiro, Deidiane Elisa; Casarotto, Plinio Cabrera; Spiacci, Ailton Jr; Fernandes, Gabriel Gripp; Pinheiro, Lucas César; Tanus-Santos, José Eduardo; Zangrossi, Hélio Jr; Guimarães, Francisco Silveira; Joca, Samia Regiane Lourenço; Biojone, Caroline.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 93, No. July, 2019, p. 232-239.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Ribeiro, DE, Casarotto, PC, Spiacci, AJ, Fernandes, GG, Pinheiro, LC, Tanus-Santos, JE, Zangrossi, HJ, Guimarães, FS, Joca, SRL & Biojone, C 2019, 'Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 93, no. July, pp. 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

APA

Ribeiro, D. E., Casarotto, P. C., Spiacci, A. J., Fernandes, G. G., Pinheiro, L. C., Tanus-Santos, J. E., Zangrossi, H. J., Guimarães, F. S., Joca, S. R. L., & Biojone, C. (2019). Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93(July), 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

CBE

Ribeiro DE, Casarotto PC, Spiacci AJ, Fernandes GG, Pinheiro LC, Tanus-Santos JE, Zangrossi HJ, Guimarães FS, Joca SRL, Biojone C. 2019. Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93(July):232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

MLA

Ribeiro, Deidiane Elisa et al. "Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019, 93(July). 232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

Vancouver

Ribeiro DE, Casarotto PC, Spiacci AJ, Fernandes GG, Pinheiro LC, Tanus-Santos JE et al. Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019;93(July):232-239. https://doi.org/10.1016/j.pnpbp.2019.04.007

Author

Ribeiro, Deidiane Elisa ; Casarotto, Plinio Cabrera ; Spiacci, Ailton Jr ; Fernandes, Gabriel Gripp ; Pinheiro, Lucas César ; Tanus-Santos, José Eduardo ; Zangrossi, Hélio Jr ; Guimarães, Francisco Silveira ; Joca, Samia Regiane Lourenço ; Biojone, Caroline. / Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 ; Vol. 93, No. July. pp. 232-239.

Bibtex

@article{00348b2176ac4eacbe5a7d77bc3ba38c,
title = "Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine",
abstract = "Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se when injected into the dPAG. Based on these findings, we hypothesize that nitric oxide synthase (NOS) inhibitors would have panicolytic properties associated with increased BDNF signaling in the dPAG. We observed that the repeated (7 days), but not acute (1 day), systemic administration of the NOS inhibitor aminoguanidine (AMG; 15 mg/kg/day) increased the latency to escape from the open arm of the elevated T-maze (ETM) and inhibited the number of jumps in hypoxia-induced escape reaction in rats, suggesting a panicolytic-like effect. Repeated, but not acute, AMG administration (15 mg/kg) also decreased nitrite levels and increased TRKB phosphorylation at residues Y706/7 in the dPAG. Notwithstanding the lack of AMG effect on total BDNF levels in this structure, the microinjection of the TRK antagonist K252a into the dPAG blocked the anti-escape effect of this drug in the ETM. Taken together our data suggest that the inhibition of NO production by AMG increases the levels of pTRKB, which is required for the panicolytic-like effect observed.",
keywords = "BDNF, dPAG, Nitric oxide, Panicolytic-like effect",
author = "Ribeiro, {Deidiane Elisa} and Casarotto, {Plinio Cabrera} and Spiacci, {Ailton Jr} and Fernandes, {Gabriel Gripp} and Pinheiro, {Lucas C{\'e}sar} and Tanus-Santos, {Jos{\'e} Eduardo} and Zangrossi, {H{\'e}lio Jr} and Guimar{\~a}es, {Francisco Silveira} and Joca, {Samia Regiane Louren{\c c}o} and Caroline Biojone",
year = "2019",
doi = "10.1016/j.pnpbp.2019.04.007",
language = "English",
volume = "93",
pages = "232--239",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "July",

}

RIS

TY - JOUR

T1 - Activation of the TRKB receptor mediates the panicolytic-like effect of the NOS inhibitor aminoguanidine

AU - Ribeiro, Deidiane Elisa

AU - Casarotto, Plinio Cabrera

AU - Spiacci, Ailton Jr

AU - Fernandes, Gabriel Gripp

AU - Pinheiro, Lucas César

AU - Tanus-Santos, José Eduardo

AU - Zangrossi, Hélio Jr

AU - Guimarães, Francisco Silveira

AU - Joca, Samia Regiane Lourenço

AU - Biojone, Caroline

PY - 2019

Y1 - 2019

N2 - Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se when injected into the dPAG. Based on these findings, we hypothesize that nitric oxide synthase (NOS) inhibitors would have panicolytic properties associated with increased BDNF signaling in the dPAG. We observed that the repeated (7 days), but not acute (1 day), systemic administration of the NOS inhibitor aminoguanidine (AMG; 15 mg/kg/day) increased the latency to escape from the open arm of the elevated T-maze (ETM) and inhibited the number of jumps in hypoxia-induced escape reaction in rats, suggesting a panicolytic-like effect. Repeated, but not acute, AMG administration (15 mg/kg) also decreased nitrite levels and increased TRKB phosphorylation at residues Y706/7 in the dPAG. Notwithstanding the lack of AMG effect on total BDNF levels in this structure, the microinjection of the TRK antagonist K252a into the dPAG blocked the anti-escape effect of this drug in the ETM. Taken together our data suggest that the inhibition of NO production by AMG increases the levels of pTRKB, which is required for the panicolytic-like effect observed.

AB - Nitric oxide (NO) triggers escape reactions in the dorsal periaqueductal gray matter (dPAG), a core structure mediating panic-associated response, and decreases the release of BDNF in vitro. BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se when injected into the dPAG. Based on these findings, we hypothesize that nitric oxide synthase (NOS) inhibitors would have panicolytic properties associated with increased BDNF signaling in the dPAG. We observed that the repeated (7 days), but not acute (1 day), systemic administration of the NOS inhibitor aminoguanidine (AMG; 15 mg/kg/day) increased the latency to escape from the open arm of the elevated T-maze (ETM) and inhibited the number of jumps in hypoxia-induced escape reaction in rats, suggesting a panicolytic-like effect. Repeated, but not acute, AMG administration (15 mg/kg) also decreased nitrite levels and increased TRKB phosphorylation at residues Y706/7 in the dPAG. Notwithstanding the lack of AMG effect on total BDNF levels in this structure, the microinjection of the TRK antagonist K252a into the dPAG blocked the anti-escape effect of this drug in the ETM. Taken together our data suggest that the inhibition of NO production by AMG increases the levels of pTRKB, which is required for the panicolytic-like effect observed.

KW - BDNF

KW - dPAG

KW - Nitric oxide

KW - Panicolytic-like effect

UR - http://www.scopus.com/inward/record.url?scp=85064453852&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2019.04.007

DO - 10.1016/j.pnpbp.2019.04.007

M3 - Journal article

C2 - 30991078

AN - SCOPUS:85064453852

VL - 93

SP - 232

EP - 239

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 0278-5846

IS - July

ER -