Irene van den Berg, INRA, UMR1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, Denmark
Bernt Guldbrandtsen, Denmark
C Hozé, INRA, UMR1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, France
Rasmus Froberg Brøndum, Denmark
Didier A Boichard, INRA, UMR1313 Génétique Animale et Biologie Intégrative, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, France
Our objective was to investigate the potential benefits of using sequence data to improve across breed genomic prediction, using data from five French and Danish dairy cattle breeds. First, QTL for protein yield were detected using high density genotypes. Part of the QTL detected within breed was shared across breed. Second, sequence data was used to quantify the loss in prediction reliabilities that results from using genomic markers rather than the causal variants. 50, 100 or 250 causative mutations were simulated and different sets of prediction markers were used to predict genomic relationships at causative mutations. Prediction of genomic relationships at causative mutations was most accurate when predicted by a selective number of markers within 1 Kb of the causative mutations. Whole-genome sequence data can help to get closer to the causative mutations and therefore improve genomic prediction across breed
Original language
English
Publication year
17 Aug 2014
Number of pages
3
Publication status
Published - 17 Aug 2014
Event
10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada Duration: 17 Aug 2014 → 22 Aug 2014 Conference number: 10th
Conference
Conference
10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Number
10th
Location
The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
Country
Canada
City
Vancouver
Period
17/08/2014 → 22/08/2014
Research areas
dairy cattle, across breed, genomic prediction , QTL