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Across Breed QTL Detection and Genomic Prediction in French and Danish Dairy Cattle Breeds

Research output: Contribution to conferencePosterResearch

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  • Paper

    Accepted manuscript, 494 KB, PDF document

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  • Irene van den Berg, INRA, UMR1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, Denmark
  • Bernt Guldbrandtsen, Denmark
  • C Hozé, INRA, UMR1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, France
  • Rasmus Froberg Brøndum, Denmark
  • Didier A Boichard, INRA, UMR1313 Génétique Animale et Biologie Intégrative, AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, Paris, France, France
  • Mogens Sandø Lund
Our objective was to investigate the potential benefits of using sequence data to improve across breed genomic prediction, using data from five French and Danish dairy cattle breeds. First, QTL for protein yield were detected using high density genotypes. Part of the QTL detected within breed was shared across breed. Second, sequence data was used to quantify the loss in prediction reliabilities that results from using genomic markers rather than the causal variants. 50, 100 or 250 causative mutations were simulated and different sets of prediction markers were used to predict genomic relationships at causative mutations. Prediction of genomic relationships at causative mutations was most accurate when predicted by a selective number of markers within 1 Kb of the causative mutations. Whole-genome sequence data can help to get closer to the causative mutations and therefore improve genomic prediction across breed
Original languageEnglish
Publication year17 Aug 2014
Number of pages1
Publication statusPublished - 17 Aug 2014
Event10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Duration: 17 Aug 201422 Aug 2014
Conference number: 10th

Conference

Conference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Number10th
LocationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
CountryCanada
CityVancouver
Period17/08/201422/08/2014

    Research areas

  • dairy cattle, across breed, genomic prediction , QTL

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