Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

Esben Kjær Unmack Larsen; Thomas Nielsen; Thomas Wittenborn; Louise Munk Rydtoft; Arcot R. Lokanathan; Line Hansen; Leif Østergaard; Peter Kingshott; Kenneth A Howard; Flemming Besenbacher; Niels Christian Nielsen; Jørgen Kjems

doi:10.1039/C2NR11554A

Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

Esben Kjær Unmack Larsen, Thomas Nielsen, Thomas Wittenborn, Louise Munk Rydtoft, Arcot R. Lokanathan, Line Hansen, Leif Østergaard, Peter Kingshott, Kenneth A Howard, Flemming Besenbacher, Niels Christian Nielsen, Jørgen Kjems

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333–20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da

Original language	English
Journal	Nanoscale
Volume	4
Issue	7
Pages (from-to)	2352-2361
Number of pages	10
ISSN	2040-3364
DOIs	https://doi.org/10.1039/C2NR11554A
Publication status	Published - 6 Mar 2012

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Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C., & Kjems, J. (2012). Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors. Nanoscale, 4(7), 2352-2361 . https://doi.org/10.1039/C2NR11554A

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title = "Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors",

abstract = "Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333–20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da",

author = "Larsen, {Esben Kj{\ae}r Unmack} and Thomas Nielsen and Thomas Wittenborn and Rydtoft, {Louise Munk} and Lokanathan, {Arcot R.} and Line Hansen and Leif {\O}stergaard and Peter Kingshott and Howard, {Kenneth A} and Flemming Besenbacher and Nielsen, {Niels Christian} and J{\o}rgen Kjems",

year = "2012",

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doi = "10.1039/C2NR11554A",

language = "English",

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publisher = "Royal Society of Chemistry",

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Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors. / Larsen, Esben Kjær Unmack; Nielsen, Thomas ; Wittenborn, Thomas et al.
In: Nanoscale, Vol. 4, No. 7, 06.03.2012, p. 2352-2361 .

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

AU - Larsen, Esben Kjær Unmack

AU - Nielsen, Thomas

AU - Wittenborn, Thomas

AU - Rydtoft, Louise Munk

AU - Lokanathan, Arcot R.

AU - Hansen, Line

AU - Østergaard, Leif

AU - Kingshott, Peter

AU - Howard, Kenneth A

AU - Besenbacher, Flemming

AU - Nielsen, Niels Christian

AU - Kjems, Jørgen

PY - 2012/3/6

Y1 - 2012/3/6

N2 - Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333–20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da

AB - Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333–20 000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (Mw) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating Mw of 10 000 Da

U2 - 10.1039/C2NR11554A

DO - 10.1039/C2NR11554A

M3 - Journal article

SN - 2040-3364

VL - 4

SP - 2352

EP - 2361

JO - Nanoscale

JF - Nanoscale

IS - 7

ER -

Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

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