Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7

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  • Mette Falkenberg Krantz, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Ditte Ellersgaard, Capital Region of Denmark, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Klaus Kaae Andersen, Danish Cancer Society
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  • Nicoline Hemager, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Camilla Christiani, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Katrine Søborg Spang, Child and Adolescent Mental Health Center, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Birgitte Klee Burton, University of Copenhagen, Child and Adolescent Mental Health Center
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  • Maja Gregersen, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Anne Søndergaard, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Aja Greve
  • Ditte Lou Gantriis
  • Jessica Ohland, Capital Region of Denmark, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Preben Bo Mortensen
  • Thomas Werge, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Capitol Region of Denmark
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  • Ron Nudel, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Capitol Region of Denmark
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  • Yunpeng Wang, University of Oslo
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  • David M. Hougaard, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Statens Serum Institut
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  • Kerstin Jessica Plessen, Capital Region of Denmark, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research, University of Lausanne
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  • Vibeke Bliksted
  • Jens Richardt Møllegaard Jepsen, Capital Region of Denmark, Child and Adolescent Mental Health Center, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Capitol Region of Denmark
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  • Anne A.E. Thorup, Capital Region of Denmark, University of Copenhagen, Child and Adolescent Mental Health Center, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research
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  • Ole Mors
  • Merete Nordentoft, Capital Region of Denmark, University of Copenhagen, IPSYCH -The Lundbeck Foundation Initiative for Integrative Psychiatric Research

Objective: Children with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precursors to examine whether they distribute evenly across familial high risk (FHR) children or if they cluster among a smaller group. Since such examination holds the potential to identify high and low risk of severe mental illness groups, we aimed to cluster FHR and control children affected to various degrees. Method: In The Danish High Risk and Resilience Study VIA 7, a clinical cohort study, 514 7-year-old children with FHR-SZ or FHR-BP and matched controls were assessed in domains of motor function, neurocognition, emotional control, behavior, social cognition, self-perception, language, psychotic experiences, and psychopathology, and grouped using cluster analysis. Associations between clusters and parents' level of education, functioning, caregiver status, child's level of stimulation and support in the home, and polygenic risk scores were examined. Results: A total of four groups including one of broadly affected children were identified. The broadly affected group was represented 4-5-fold (18.1%) amongst FHR-SZ children and 2-3-fold (10.2%) amongst FHR-BP children, compared to controls (4.1%) (P <. 001), and the broadly affected group had lower levels of caregiver functioning (P <. 001) and stimulation and support at home (P <. 001). Conclusion: Precursors of severe mental illness distribute unevenly among FHR children; while approximately half are not affected in any domains, the other half are affected to various degrees. Targeted support towards the affected groups is indicated.

Original languageEnglish
Article numbersgac010
JournalSchizophrenia Bulletin Open
Volume3
Issue1
Number of pages16
ISSN2632-7899
DOIs
Publication statusPublished - Jan 2022

    Research areas

  • bipolar disorder, cross-domain, distribution, familial high-risk, schizophrenia

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