Access to 1,2-dihydroisoquinolines through gold-catalyzed formal [4+2] cycloaddition

Zhuo Xin, Søren Kramer, Jacob Overgaard, Troels Skrydstrup

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


A new synthetic route to the privileged 1,2-dihydroisoquinolines is reported. This method, which relies on a gold-catalyzed formal [4+2] cycloaddition between ynamides and imines, provides a new retrosynthetic disconnection of the 1,2-dihydroisoquinoline core by installing the 1,8a C-C and 2,3 C-N bonds in one step. Both aldimines and ketimines can be used as substrates. In addition, one example of dihydrofuropyridine synthesis is also demonstrated.
Original languageEnglish
JournalChemistry: A European Journal
Pages (from-to)7926-7930
Number of pages5
Publication statusPublished - 23 Jun 2014


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