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ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE

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ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. / Lisi, Simonetta; Madsen, Peder; Botta, Roberta; Petersen, Claus Munck; Nykjær, Anders; Latrofa, Francesco; Vitti, Paolo; Marinò, Michele.

In: Endocrine Practice, Vol. 21, No. 9, 09.2015, p. 981-985.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Lisi, S, Madsen, P, Botta, R, Petersen, CM, Nykjær, A, Latrofa, F, Vitti, P & Marinò, M 2015, 'ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE', Endocrine Practice, vol. 21, no. 9, pp. 981-985. https://doi.org/10.4158/EP15697.OR

APA

Lisi, S., Madsen, P., Botta, R., Petersen, C. M., Nykjær, A., Latrofa, F., Vitti, P., & Marinò, M. (2015). ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. Endocrine Practice, 21(9), 981-985. https://doi.org/10.4158/EP15697.OR

CBE

Lisi S, Madsen P, Botta R, Petersen CM, Nykjær A, Latrofa F, Vitti P, Marinò M. 2015. ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. Endocrine Practice. 21(9):981-985. https://doi.org/10.4158/EP15697.OR

MLA

Lisi, Simonetta et al. "ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE". Endocrine Practice. 2015, 21(9). 981-985. https://doi.org/10.4158/EP15697.OR

Vancouver

Author

Lisi, Simonetta ; Madsen, Peder ; Botta, Roberta ; Petersen, Claus Munck ; Nykjær, Anders ; Latrofa, Francesco ; Vitti, Paolo ; Marinò, Michele. / ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. In: Endocrine Practice. 2015 ; Vol. 21, No. 9. pp. 981-985.

Bibtex

@article{c451ffb8c53548f38db421f40c7276df,
title = "ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE",
abstract = "OBJECTIVE: The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.METHODS: We measured free T4, thyroid-stimulating hormone (TSH) and Tg serum levels and studied thyroid morphology in 14 sortilin-deficient (Sort1)(-/-)and 12 wildtype (WT) mice.RESULTS: Serum free T4 levels did not differ between Sort1(-/-)and WT females but were significantly lower in Sort1(-/-)males compared with WT (P = .0424). Neither serum TSH nor Tg levels differed between Sort1(-/-)and WT mice, regardless of sex. On the same line, no thyroid histology differences were observed.CONCLUSION: Our findings seem to exclude a role of sortilin in thyroid hormone secretion, although it is possible that the absence of sortilin may result in a thyroid phenotype if combined with other molecular defects of thyroid hormone synthesis and secretion or under iodine deficiency.ABBREVIATIONS: T4 = thyroxine Sort1 = Sortilin 1 Tg = thyroglobulin TSH = thyroid-stimulating hormone WT = wild type.",
author = "Simonetta Lisi and Peder Madsen and Roberta Botta and Petersen, {Claus Munck} and Anders Nykj{\ae}r and Francesco Latrofa and Paolo Vitti and Michele Marin{\`o}",
year = "2015",
month = sep,
doi = "10.4158/EP15697.OR",
language = "English",
volume = "21",
pages = "981--985",
journal = "Endocrine Practice",
issn = "1530-891X",
publisher = "American Association of Clinical Endocrinology",
number = "9",

}

RIS

TY - JOUR

T1 - ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE

AU - Lisi, Simonetta

AU - Madsen, Peder

AU - Botta, Roberta

AU - Petersen, Claus Munck

AU - Nykjær, Anders

AU - Latrofa, Francesco

AU - Vitti, Paolo

AU - Marinò, Michele

PY - 2015/9

Y1 - 2015/9

N2 - OBJECTIVE: The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.METHODS: We measured free T4, thyroid-stimulating hormone (TSH) and Tg serum levels and studied thyroid morphology in 14 sortilin-deficient (Sort1)(-/-)and 12 wildtype (WT) mice.RESULTS: Serum free T4 levels did not differ between Sort1(-/-)and WT females but were significantly lower in Sort1(-/-)males compared with WT (P = .0424). Neither serum TSH nor Tg levels differed between Sort1(-/-)and WT mice, regardless of sex. On the same line, no thyroid histology differences were observed.CONCLUSION: Our findings seem to exclude a role of sortilin in thyroid hormone secretion, although it is possible that the absence of sortilin may result in a thyroid phenotype if combined with other molecular defects of thyroid hormone synthesis and secretion or under iodine deficiency.ABBREVIATIONS: T4 = thyroxine Sort1 = Sortilin 1 Tg = thyroglobulin TSH = thyroid-stimulating hormone WT = wild type.

AB - OBJECTIVE: The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.METHODS: We measured free T4, thyroid-stimulating hormone (TSH) and Tg serum levels and studied thyroid morphology in 14 sortilin-deficient (Sort1)(-/-)and 12 wildtype (WT) mice.RESULTS: Serum free T4 levels did not differ between Sort1(-/-)and WT females but were significantly lower in Sort1(-/-)males compared with WT (P = .0424). Neither serum TSH nor Tg levels differed between Sort1(-/-)and WT mice, regardless of sex. On the same line, no thyroid histology differences were observed.CONCLUSION: Our findings seem to exclude a role of sortilin in thyroid hormone secretion, although it is possible that the absence of sortilin may result in a thyroid phenotype if combined with other molecular defects of thyroid hormone synthesis and secretion or under iodine deficiency.ABBREVIATIONS: T4 = thyroxine Sort1 = Sortilin 1 Tg = thyroglobulin TSH = thyroid-stimulating hormone WT = wild type.

U2 - 10.4158/EP15697.OR

DO - 10.4158/EP15697.OR

M3 - Journal article

C2 - 26121464

VL - 21

SP - 981

EP - 985

JO - Endocrine Practice

JF - Endocrine Practice

SN - 1530-891X

IS - 9

ER -