A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry

Pia I. Pietersen; Theresa Junker; Sarah Stougaard; Francis X. Keeley; Brunolf Lagerveld; David Breen; Alexander King; Tommy K. Nielsen; Marco van Strijen; Julien Garnon; Des Alcorn; Eric de Kerviler; Patricia Zondervan; Tze M. Wah; Ole Graumann

doi:10.1016/S0302-2838(24)01201-6

A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry

Pia I. Pietersen, Theresa Junker, Sarah Stougaard, Francis X. Keeley, Brunolf Lagerveld, David Breen, Alexander King, Tommy K. Nielsen, Marco van Strijen, Julien Garnon, Des Alcorn, Eric de Kerviler, Patricia Zondervan, Tze M. Wah, Ole Graumann

Department of Clinical Medicine - Department of Urology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review

Abstract

Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys. Material and Methods: Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared. Results: Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m 2, and the mean 3-month post-operative eGFR was 49.6 ± 16.5 mL/min/1.73 m 2. Mean eGFR reduction was − 6.2 mL/min/1.73 m 2 corresponding to 11.1% (p = 0.01). No patients changed chronic kidney disease group to severe or end-stage chronic kidney disease (stage IV or V). No patients required post-procedure dialysis. Conclusion: Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR. Level of Evidence 3: Observational study. Graphical Abstract: (Figure presented.)

Original language	English
Journal	European Urology
Volume	85
Issue	Suppl. 1
Pages (from-to)	S1555
ISSN	1828-6569
DOIs	https://doi.org/10.1016/S0302-2838(24)01201-6
Publication status	Published - Mar 2024

Keywords

Cryoablation
Image-guided
Renal cell carcinoma
Renal function
Renal masses
Solitary kidney
Glomerular Filtration Rate
Prospective Studies
Tomography
X-Ray Computed/methods
Europe
Humans
Middle Aged
Male
Treatment Outcome
Surgery
Computer-Assisted/methods
Carcinoma
Renal Cell/surgery
Radiography
Interventional/methods
Kidney/surgery
Solitary Kidney/surgery
Cryosurgery/methods
Female
Registries
Aged
Kidney Neoplasms/surgery

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10.1016/S0302-2838(24)01201-6

Cite this

Pietersen, P. I., Junker, T., Stougaard, S., Keeley, F. X., Lagerveld, B., Breen, D., King, A., Nielsen, T. K., van Strijen, M., Garnon, J., Alcorn, D., de Kerviler, E., Zondervan, P., Wah, T. M., & Graumann, O. (2024). A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry. European Urology, 85(Suppl. 1), S1555. https://doi.org/10.1016/S0302-2838(24)01201-6

@article{caa9565ff415431597eea4d5d1e2afd3,

title = "A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry",

abstract = "Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys. Material and Methods: Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared. Results: Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m 2, and the mean 3-month post-operative eGFR was 49.6 ± 16.5 mL/min/1.73 m 2. Mean eGFR reduction was − 6.2 mL/min/1.73 m 2 corresponding to 11.1% (p = 0.01). No patients changed chronic kidney disease group to severe or end-stage chronic kidney disease (stage IV or V). No patients required post-procedure dialysis. Conclusion: Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR. Level of Evidence 3: Observational study. Graphical Abstract: (Figure presented.)",

keywords = "Cryoablation, Image-guided, Renal cell carcinoma, Renal function, Renal masses, Solitary kidney, Glomerular Filtration Rate, Prospective Studies, Tomography, X-Ray Computed/methods, Europe, Humans, Middle Aged, Male, Treatment Outcome, Surgery, Computer-Assisted/methods, Carcinoma, Renal Cell/surgery, Radiography, Interventional/methods, Kidney/surgery, Solitary Kidney/surgery, Cryosurgery/methods, Female, Registries, Aged, Kidney Neoplasms/surgery",

author = "Pietersen, {Pia I.} and Theresa Junker and Sarah Stougaard and Keeley, {Francis X.} and Brunolf Lagerveld and David Breen and Alexander King and Nielsen, {Tommy K.} and {van Strijen}, Marco and Julien Garnon and Des Alcorn and {de Kerviler}, Eric and Patricia Zondervan and Wah, {Tze M.} and Ole Graumann",

note = "39th Annual EAU Congress ; Conference date: 05-04-2024 Through 08-04-2024",

year = "2024",

month = mar,

doi = "10.1016/S0302-2838(24)01201-6",

language = "English",

volume = "85",

pages = "S1555",

journal = "European Urology",

issn = "1828-6569",

publisher = "EdizioniEdra",

number = "Suppl. 1",

}

Pietersen, PI, Junker, T, Stougaard, S, Keeley, FX, Lagerveld, B, Breen, D, King, A, Nielsen, TK, van Strijen, M, Garnon, J, Alcorn, D, de Kerviler, E, Zondervan, P, Wah, TM & Graumann, O 2024, 'A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry', European Urology, vol. 85, no. Suppl. 1, pp. S1555. https://doi.org/10.1016/S0302-2838(24)01201-6

A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry. / Pietersen, Pia I.; Junker, Theresa; Stougaard, Sarah et al.
In: European Urology, Vol. 85, No. Suppl. 1, 03.2024, p. S1555.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Conference abstract in journal › Research › peer-review

TY - ABST

T1 - A0628 - Renal function after CT-guided cryoablation of small renal tumours in patients with solitary kidney - An analysis of european multinational prospective EURECA registry

AU - Pietersen, Pia I.

AU - Junker, Theresa

AU - Stougaard, Sarah

AU - Keeley, Francis X.

AU - Lagerveld, Brunolf

AU - Breen, David

AU - King, Alexander

AU - Nielsen, Tommy K.

AU - van Strijen, Marco

AU - Garnon, Julien

AU - Alcorn, Des

AU - de Kerviler, Eric

AU - Zondervan, Patricia

AU - Wah, Tze M.

AU - Graumann, Ole

N1 - 39th Annual EAU Congress ; Conference date: 05-04-2024 Through 08-04-2024

PY - 2024/3

Y1 - 2024/3

N2 - Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys. Material and Methods: Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared. Results: Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m 2, and the mean 3-month post-operative eGFR was 49.6 ± 16.5 mL/min/1.73 m 2. Mean eGFR reduction was − 6.2 mL/min/1.73 m 2 corresponding to 11.1% (p = 0.01). No patients changed chronic kidney disease group to severe or end-stage chronic kidney disease (stage IV or V). No patients required post-procedure dialysis. Conclusion: Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR. Level of Evidence 3: Observational study. Graphical Abstract: (Figure presented.)

AB - Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys. Material and Methods: Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared. Results: Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m 2, and the mean 3-month post-operative eGFR was 49.6 ± 16.5 mL/min/1.73 m 2. Mean eGFR reduction was − 6.2 mL/min/1.73 m 2 corresponding to 11.1% (p = 0.01). No patients changed chronic kidney disease group to severe or end-stage chronic kidney disease (stage IV or V). No patients required post-procedure dialysis. Conclusion: Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR. Level of Evidence 3: Observational study. Graphical Abstract: (Figure presented.)

KW - Cryoablation

KW - Image-guided

KW - Renal cell carcinoma

KW - Renal function

KW - Renal masses

KW - Solitary kidney

KW - Glomerular Filtration Rate

KW - Prospective Studies

KW - Tomography

KW - X-Ray Computed/methods

KW - Europe

KW - Humans

KW - Middle Aged

KW - Male

KW - Treatment Outcome

KW - Surgery

KW - Computer-Assisted/methods

KW - Carcinoma

KW - Renal Cell/surgery

KW - Radiography

KW - Interventional/methods

KW - Kidney/surgery

KW - Solitary Kidney/surgery

KW - Cryosurgery/methods

KW - Female

KW - Registries

KW - Aged

KW - Kidney Neoplasms/surgery

U2 - 10.1016/S0302-2838(24)01201-6

DO - 10.1016/S0302-2838(24)01201-6

M3 - Conference abstract in journal

SN - 1828-6569

VL - 85

SP - S1555

JO - European Urology

JF - European Urology

IS - Suppl. 1

ER -