A Visual Review of the Human Pathogen Streptococcus pneumoniae

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A Visual Review of the Human Pathogen Streptococcus pneumoniae. / Engholm, Ditte Høyer; Kilian, Mogens; Goodsell, David; Andersen, Ebbe Sloth; Kjærgaard, Rikke Schmidt.

In: F E M S Microbiology Reviews, 05.10.2017.

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@article{fa5080041da84139a7853cda1f8f4b86,
title = "A Visual Review of the Human Pathogen Streptococcus pneumoniae",
abstract = "Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To highlight the molecular basis of this problem, we have portrayed essential biological processes of the pneumococcal life cycle in eight watercolor paintings. The paintings are done to a consistent nanometer scale based on currently available data from structural biology and proteomics. In this review article, the paintings are used to provide a visual review of protein synthesis, carbohydrate metabolism, cell wall synthesis, cell division, teichoic acid synthesis, virulence, transformation and pilus synthesis based on the available scientific literature within the field of pneumococcal biology. Visualization of the molecular details of these processes reveals several scientific questions about how molecular components of the pneumococcal cell are organized to allow biological function to take place. By the presentation of this visual review, we intend to stimulate scientific discussion, aid in the generation of scientific hypotheses and increase public awareness. A narrated video describing the biological processes in the context of a whole-cell illustration accompany this article.",
author = "Engholm, {Ditte H{\o}yer} and Mogens Kilian and David Goodsell and Andersen, {Ebbe Sloth} and Kj{\ae}rgaard, {Rikke Schmidt}",
year = "2017",
month = "10",
day = "5",
doi = "10.1093/femsre/fux037",
language = "English",
journal = "F E M S Microbiology Reviews",
issn = "0168-6445",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - A Visual Review of the Human Pathogen Streptococcus pneumoniae

AU - Engholm, Ditte Høyer

AU - Kilian, Mogens

AU - Goodsell, David

AU - Andersen, Ebbe Sloth

AU - Kjærgaard, Rikke Schmidt

PY - 2017/10/5

Y1 - 2017/10/5

N2 - Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To highlight the molecular basis of this problem, we have portrayed essential biological processes of the pneumococcal life cycle in eight watercolor paintings. The paintings are done to a consistent nanometer scale based on currently available data from structural biology and proteomics. In this review article, the paintings are used to provide a visual review of protein synthesis, carbohydrate metabolism, cell wall synthesis, cell division, teichoic acid synthesis, virulence, transformation and pilus synthesis based on the available scientific literature within the field of pneumococcal biology. Visualization of the molecular details of these processes reveals several scientific questions about how molecular components of the pneumococcal cell are organized to allow biological function to take place. By the presentation of this visual review, we intend to stimulate scientific discussion, aid in the generation of scientific hypotheses and increase public awareness. A narrated video describing the biological processes in the context of a whole-cell illustration accompany this article.

AB - Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To highlight the molecular basis of this problem, we have portrayed essential biological processes of the pneumococcal life cycle in eight watercolor paintings. The paintings are done to a consistent nanometer scale based on currently available data from structural biology and proteomics. In this review article, the paintings are used to provide a visual review of protein synthesis, carbohydrate metabolism, cell wall synthesis, cell division, teichoic acid synthesis, virulence, transformation and pilus synthesis based on the available scientific literature within the field of pneumococcal biology. Visualization of the molecular details of these processes reveals several scientific questions about how molecular components of the pneumococcal cell are organized to allow biological function to take place. By the presentation of this visual review, we intend to stimulate scientific discussion, aid in the generation of scientific hypotheses and increase public awareness. A narrated video describing the biological processes in the context of a whole-cell illustration accompany this article.

U2 - 10.1093/femsre/fux037

DO - 10.1093/femsre/fux037

M3 - Journal article

JO - F E M S Microbiology Reviews

JF - F E M S Microbiology Reviews

SN - 0168-6445

ER -