A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

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DOI

  • Marta Compte, Department of Antibody Engineering, Leadartis S.L.
  • ,
  • Seandean Lykke Harwood
  • Ines G. Muñoz, Spanish National Cancer Research Centre (CNIO)
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  • Rocio Navarro, Hospital Universitario Puerta de Hierro, Madrid, Spain.
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  • Manuela Zonca, Department of Antibody Engineering, Leadartis S.L.
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  • Gema Perez-Chacon, CSIC-UAM - Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), Instituto de Investigación Sanitaria La Paz (IdiPaz)
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  • Ainhoa Erce-Llamazares, Department of Antibody Engineering, Leadartis S.L.
  • ,
  • Nekane Merino, CIC BioGUNE
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  • Antonio Tapia-Galisteo, Hospital Universitario Puerta de Hierro, Madrid, Spain.
  • ,
  • Angel M. Cuesta, Hospital Universitario Puerta de Hierro, Madrid, Spain.
  • ,
  • Kasper Mikkelsen
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  • Eduardo Caleiras, Spanish National Cancer Research Centre (CNIO)
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  • Natalia Nuñez-Prado, Hospital Universitario Puerta de Hierro, Madrid, Spain.
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  • M. Angela Aznar, University of Navarra
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  • Simon Lykkemark
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  • Jorge Martínez-Torrecuadrada, Spanish National Cancer Research Centre (CNIO)
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  • Ignacio Melero, University of Navarra, University Clinic, Instituto de Investigación Sanitaria de Navarra (IdiSNA), CIBERONC-Centro virtual de Investigación Biomédica en red de Oncología
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  • Francisco J. Blanco, CIC BioGUNE, Ikerbasque, the Basque Foundation for Science
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  • Jorge Bernardino de la Serna, Rutherford Appleton Laboratory, King's College London
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  • Juan M. Zapata, CSIC-UAM - Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), Instituto de Investigación Sanitaria La Paz (IdiPaz)
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  • Laura Sanz, Hospital Universitario Puerta de Hierro, Madrid, Spain.
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  • Luis Alvarez-Vallina, Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (i+12)
Original languageEnglish
Article number4809
JournalNature Communications
Volume9
Number of pages13
ISSN2041-1723
DOIs
Publication statusPublished - 15 Nov 2018

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