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A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.

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  • Interdisciplinary Nanoscience Center
  • iNano-School
  • Department of Molecular Biology
  • Royal Danish Library
Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
Original languageEnglish
Pages (from-to)3546-52
Number of pages6
Publication statusPublished - 2005

    Research areas

  • Animals, Leukemia Virus, Murine, Leukemia, Experimental, Lymphoma, T-Cell, Mice, Mice, Inbred BALB C, NFATC Transcription Factors, Retroviridae Infections, Tumor Suppressor Proteins, Tumor Virus Infections, Virus Integration

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