Aarhus University Seal / Aarhus Universitets segl

A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Interdisciplinary Nanoscience Center
  • iNano-School
  • Department of Molecular Biology
  • Royal Danish Library
Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
Original languageEnglish
JournalBlood
Volume106
Issue10
Pages (from-to)3546-52
Number of pages6
ISSN0006-4971
DOIs
Publication statusPublished - 2005

    Research areas

  • Animals, Leukemia Virus, Murine, Leukemia, Experimental, Lymphoma, T-Cell, Mice, Mice, Inbred BALB C, NFATC Transcription Factors, Retroviridae Infections, Tumor Suppressor Proteins, Tumor Virus Infections, Virus Integration

See relations at Aarhus University Citationformats

ID: 12358176