A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Marta Compte; Seandean Lykke Harwood; Ines G. Muñoz; Rocio Navarro; Manuela Zonca; Gema Perez-Chacon; Ainhoa Erce-Llamazares; Nekane Merino; Antonio Tapia-Galisteo; Angel M. Cuesta; Kasper Mikkelsen; Eduardo Caleiras; Natalia Nuñez-Prado; M. Angela Aznar; Simon Lykkemark; Jorge Martínez-Torrecuadrada; Ignacio Melero; Francisco J. Blanco; Jorge Bernardino de la Serna; Juan M. Zapata; Laura Sanz; Luis Alvarez-Vallina

doi:10.1038/s41467-018-07195-w

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. ZapataLaura Sanz, Luis Alvarez-Vallina

Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

1 Citation (Scopus)

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Original language	English
Article number	4809
Journal	Nature Communications
Volume	9
Number of pages	13
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-018-07195-w
Publication status	Published - 15 Nov 2018

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s41467-018-07195-wFinal published version, 1.96 MBLicence: CC BY

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Compte, M., Harwood, S. L., Muñoz, I. G., Navarro, R., Zonca, M., Perez-Chacon, G., Erce-Llamazares, A., Merino, N., Tapia-Galisteo, A., Cuesta, A. M., Mikkelsen, K., Caleiras, E., Nuñez-Prado, N., Aznar, M. A., Lykkemark, S., Martínez-Torrecuadrada, J., Melero, I., Blanco, F. J., Bernardino de la Serna, J., ... Alvarez-Vallina, L. (2018). A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nature Communications, 9, Article 4809 . https://doi.org/10.1038/s41467-018-07195-w

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title = "A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity",

author = "Marta Compte and Harwood, {Seandean Lykke} and Mu{\~n}oz, {Ines G.} and Rocio Navarro and Manuela Zonca and Gema Perez-Chacon and Ainhoa Erce-Llamazares and Nekane Merino and Antonio Tapia-Galisteo and Cuesta, {Angel M.} and Kasper Mikkelsen and Eduardo Caleiras and Natalia Nu{\~n}ez-Prado and Aznar, {M. Angela} and Simon Lykkemark and Jorge Mart{\'i}nez-Torrecuadrada and Ignacio Melero and Blanco, {Francisco J.} and {Bernardino de la Serna}, Jorge and Zapata, {Juan M.} and Laura Sanz and Luis Alvarez-Vallina",

year = "2018",

month = nov,

day = "15",

doi = "10.1038/s41467-018-07195-w",

language = "English",

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Compte, M, Harwood, SL, Muñoz, IG, Navarro, R, Zonca, M, Perez-Chacon, G, Erce-Llamazares, A, Merino, N, Tapia-Galisteo, A, Cuesta, AM, Mikkelsen, K, Caleiras, E, Nuñez-Prado, N, Aznar, MA, Lykkemark, S, Martínez-Torrecuadrada, J, Melero, I, Blanco, FJ, Bernardino de la Serna, J, Zapata, JM, Sanz, L & Alvarez-Vallina, L 2018, 'A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity', Nature Communications, vol. 9, 4809 . https://doi.org/10.1038/s41467-018-07195-w

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. / Compte, Marta; Harwood, Seandean Lykke; Muñoz, Ines G. et al.
In: Nature Communications, Vol. 9, 4809 , 15.11.2018.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

AU - Compte, Marta

AU - Harwood, Seandean Lykke

AU - Muñoz, Ines G.

AU - Navarro, Rocio

AU - Zonca, Manuela

AU - Perez-Chacon, Gema

AU - Erce-Llamazares, Ainhoa

AU - Merino, Nekane

AU - Tapia-Galisteo, Antonio

AU - Cuesta, Angel M.

AU - Mikkelsen, Kasper

AU - Caleiras, Eduardo

AU - Nuñez-Prado, Natalia

AU - Aznar, M. Angela

AU - Lykkemark, Simon

AU - Martínez-Torrecuadrada, Jorge

AU - Melero, Ignacio

AU - Blanco, Francisco J.

AU - Bernardino de la Serna, Jorge

AU - Zapata, Juan M.

AU - Sanz, Laura

AU - Alvarez-Vallina, Luis

PY - 2018/11/15

Y1 - 2018/11/15

U2 - 10.1038/s41467-018-07195-w

DO - 10.1038/s41467-018-07195-w

M3 - Journal article

C2 - 30442944

AN - SCOPUS:85056666690

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 4809

ER -