A swarm of slippery micropropellers penetrates the vitreous body of the eye

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review



  • Zhiguang Wu, Max Planck Institute for Intelligent Systems, Harbin Institute of Technology
  • ,
  • Jonas Troll, University of Stuttgart
  • ,
  • Hyeon-Ho Jeong, Max Planck Institute for Intelligent Systems
  • ,
  • Qiang Wei, Max Planck Institute for Medical Research
  • ,
  • Marius Stang, University Eye Hospital Tübingen
  • ,
  • Focke Ziemssen, University Eye Hospital Tübingen
  • ,
  • Zegao Wang
  • ,
  • Mingdong Dong
  • Sven Schnichels, University Eye Hospital Tübingen
  • ,
  • Tian Qiu, Max Planck Institute for Intelligent Systems
  • ,
  • Peer Fischer, Max Planck Institute for Intelligent Systems, University of Stuttgart

The intravitreal delivery of therapeutic agents promises major benefits in the field of ocular medicine. Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye. The use of particles promises targeted delivery but faces the challenge that most tissues including the vitreous have a tight macromolecular matrix that acts as a barrier and prevents its penetration. Here, we demonstrate novel intravitreal delivery microvehicles-slippery micropropellers-that can be actively propelled through the vitreous humor to reach the retina. The propulsion is achieved by helical magnetic micropropellers that have a liquid layer coating to minimize adhesion to the surrounding biopolymeric network. The submicrometer diameter of the propellers enables the penetration of the biopolymeric network and the propulsion through the porcine vitreous body of the eye over centimeter distances. Clinical optical coherence tomography is used to monitor the movement of the propellers and confirm their arrival on the retina near the optic disc. Overcoming the adhesion forces and actively navigating a swarm of micropropellers in the dense vitreous humor promise practical applications in ophthalmology.

Original languageEnglish
Article number4388
JournalScience Advances
Number of pages10
Publication statusPublished - 2 Nov 2018

    Research areas


See relations at Aarhus University Citationformats

Download statistics

No data available

ID: 139114281