A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

Miguel M. Álvarez-Álvarez; Daniela Zanetti; Robert Carreras-Torres; Pedro Moral; Georgios Athanasiadis

doi:10.1038/ejhg.2016.200

A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

Miguel M. Álvarez-Álvarez, Daniela Zanetti, Robert Carreras-Torres, Pedro Moral, Georgios Athanasiadis^*

^*Corresponding author for this work

Department of Molecular Biology and Genetics - Bioinformatics Research Centre (BiRC)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

38 Citations (Scopus)

Abstract

This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.

Original language	English
Journal	European Journal of Human Genetics
Volume	25
Issue	4
Pages (from-to)	472-476
Number of pages	5
ISSN	1018-4813
DOIs	https://doi.org/10.1038/ejhg.2016.200
Publication status	Published - 1 Apr 2017

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abstract = "This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.",

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A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease. / Álvarez-Álvarez, Miguel M.; Zanetti, Daniela; Carreras-Torres, Robert et al.
In: European Journal of Human Genetics, Vol. 25, No. 4, 01.04.2017, p. 472-476.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Álvarez-Álvarez, Miguel M.

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AU - Moral, Pedro

AU - Athanasiadis, Georgios

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AB - This study tries to find detectable signals of gene flow of Sub-Saharan origin into the Mediterranean in four genomic regions previously associated with coronary artery disease. A total of 366 single-nucleotide polymorphisms were genotyped in 772 individuals from 10 Mediterranean countries. Population structure analyses were performed, in which a noticeable Sub-Saharan component was found in the studied samples. The overall percentage of this Sub-Saharan component presents differences between the two Mediterranean coasts. D-statistics suggest possible Sub-Saharan introgression into one of the studied genomic regions (10q11). We also found differences in linkage disequilibrium patterns between the two Mediterranean coasts, possibly attributable to differential Sub-Saharan admixture. Our results confirm the potentially important role of human demographic history when performing epidemiological studies.

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A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

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