A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Stefan M Pfister; Miguel Reyes-Múgica; John K C Chan; Henrik Hasle; Alexander J Lazar; Sabrina Rossi; Andrea Ferrari; Jason A Jarzembowski; Kathy Pritchard-Jones; D Ashley Hill; Thomas S Jacques; Pieter Wesseling; Dolores H López Terrada; Andreas von Deimling; Christian P Kratz; Ian A Cree; Rita Alaggio

doi:10.1158/2159-8290.CD-21-1094

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Stefan M Pfister, Miguel Reyes-Múgica, John K C Chan, Henrik Hasle, Alexander J Lazar, Sabrina Rossi, Andrea Ferrari, Jason A Jarzembowski, Kathy Pritchard-Jones, D Ashley Hill, Thomas S Jacques, Pieter Wesseling, Dolores H López Terrada, Andreas von Deimling, Christian P Kratz, Ian A Cree, Rita Alaggio

Department of Clinical Medicine - Department of Paediatrics

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

131 Citations (Scopus)

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Abstract

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.

Original language	English
Journal	Cancer Discovery
Volume	12
Issue	2
Pages (from-to)	331-355
ISSN	2159-8274
DOIs	https://doi.org/10.1158/2159-8290.CD-21-1094
Publication status	Published - Feb 2022

Keywords

BETA-CATENIN
CENTRAL-NERVOUS-SYSTEM
GENETIC ALTERATIONS
GENOMIC ANALYSIS
HIGH-RISK
METHYLATION-BASED CLASSIFICATION
SOFT-TISSUE SARCOMAS
WILMS-TUMOR
WORKING GROUP
YOUNG-ADULTS

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10.1158/2159-8290.CD-21-1094

A Summary of the Inaugural WHO Classification of Pediatric TumorsFinal published version, 8.08 MBLicence: CC BY-NC-ND

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Pfister, S. M., Reyes-Múgica, M., Chan, J. K. C., Hasle, H., Lazar, A. J., Rossi, S., Ferrari, A., Jarzembowski, J. A., Pritchard-Jones, K., Hill, D. A., Jacques, T. S., Wesseling, P., López Terrada, D. H., von Deimling, A., Kratz, C. P., Cree, I. A., & Alaggio, R. (2022). A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era. Cancer Discovery, 12(2), 331-355. https://doi.org/10.1158/2159-8290.CD-21-1094

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abstract = "Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.",

keywords = "BETA-CATENIN, CENTRAL-NERVOUS-SYSTEM, GENETIC ALTERATIONS, GENOMIC ANALYSIS, HIGH-RISK, METHYLATION-BASED CLASSIFICATION, SOFT-TISSUE SARCOMAS, WILMS-TUMOR, WORKING GROUP, YOUNG-ADULTS",

author = "Pfister, {Stefan M} and Miguel Reyes-M{\'u}gica and Chan, {John K C} and Henrik Hasle and Lazar, {Alexander J} and Sabrina Rossi and Andrea Ferrari and Jarzembowski, {Jason A} and Kathy Pritchard-Jones and Hill, {D Ashley} and Jacques, {Thomas S} and Pieter Wesseling and {L{\'o}pez Terrada}, {Dolores H} and {von Deimling}, Andreas and Kratz, {Christian P} and Cree, {Ian A} and Rita Alaggio",

note = "{\textcopyright}2021 The Authors; Published by the American Association for Cancer Research.",

year = "2022",

month = feb,

doi = "10.1158/2159-8290.CD-21-1094",

language = "English",

volume = "12",

pages = "331--355",

journal = "Cancer Discovery",

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Pfister, SM, Reyes-Múgica, M, Chan, JKC, Hasle, H, Lazar, AJ, Rossi, S, Ferrari, A, Jarzembowski, JA, Pritchard-Jones, K, Hill, DA, Jacques, TS, Wesseling, P, López Terrada, DH, von Deimling, A, Kratz, CP, Cree, IA & Alaggio, R 2022, 'A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era', Cancer Discovery, vol. 12, no. 2, pp. 331-355. https://doi.org/10.1158/2159-8290.CD-21-1094

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era. / Pfister, Stefan M; Reyes-Múgica, Miguel; Chan, John K C et al.
In: Cancer Discovery, Vol. 12, No. 2, 02.2022, p. 331-355.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

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AU - Pfister, Stefan M

AU - Reyes-Múgica, Miguel

AU - Chan, John K C

AU - Hasle, Henrik

AU - Lazar, Alexander J

AU - Rossi, Sabrina

AU - Ferrari, Andrea

AU - Jarzembowski, Jason A

AU - Pritchard-Jones, Kathy

AU - Hill, D Ashley

AU - Jacques, Thomas S

AU - Wesseling, Pieter

AU - López Terrada, Dolores H

AU - von Deimling, Andreas

AU - Kratz, Christian P

AU - Cree, Ian A

AU - Alaggio, Rita

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AB - Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.

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KW - CENTRAL-NERVOUS-SYSTEM

KW - GENETIC ALTERATIONS

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KW - METHYLATION-BASED CLASSIFICATION

KW - SOFT-TISSUE SARCOMAS

KW - WILMS-TUMOR

KW - WORKING GROUP

KW - YOUNG-ADULTS

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DO - 10.1158/2159-8290.CD-21-1094

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VL - 12

SP - 331

EP - 355

JO - Cancer Discovery

JF - Cancer Discovery

IS - 2

ER -

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era

Abstract

Keywords

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