A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

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DOI

  • Josbert J Keller, Med Ctr Haaglanden, Haaglanden Medical Center, Dept Neurosurg
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  • Rogier E Ooijevaar, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Christian L Hvas
  • Elisabeth M Terveer, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Simone C Lieberknecht, Univ Hosp Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt Hospital
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  • Christoph Högenauer, Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; Center for Medical Research, Medical University of Graz, Graz, Austria.
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  • Perttu Arkkila, University of Helsinki and Helsinki University Hospital
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  • Harry Sokol, French Group of Fecal Microbiota Transplantation (GFTF)
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  • Oleksiy Gridnyev, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Francis Mégraud, University of Bordeaux and Bacteriology Laboratory
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  • Patrizia K Kump, Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; Center for Medical Research, Medical University of Graz, Graz, Austria.
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  • Radislav Nakov, Tsaritsa Yoanna University Hospital
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  • Simon D Goldenberg, King's College London, Department of Primary Care and Public Health Sciences, London, and NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust, London.
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  • Reetta Satokari, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
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  • Sergiy Tkatch, Ukranian Scientific and Practical Center of Endocrine Surgery
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  • Maurizio Sanguinetti, Italy.
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  • Giovanni Cammarota, Italy.
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  • Andrey Dorofeev, National Medical Academy of Postgraduate Education n.a. P.L. Shupic
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  • Olena Gubska, Bogomolets National Medical University
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  • Gianluca Ianiro, Italy.
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  • Eero Mattila, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
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  • Ramesh P Arasaradnam, University Hospital Coventry and Warwick
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  • Shiv K Sarin, Institute of Liver and Biliary Sciences
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  • Ajit Sood, Dayanand Medical College and Hospital
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  • Lorenza Putignani, Italy.
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  • Laurent Alric, Univ Toulouse 3, Centre National de la Recherche Scientifique (CNRS), University of Paul Sabatier - Toulouse III, PRES Universite de Toulouse, Institut de Recherche pour le Developpement (IRD), IRD, CNES, Ctr Etudes Spatiales Biosphere,CNRS,UMR5126
  • ,
  • Simon Md Baunwall
  • Juozas Kupcinskas, Lithuanian University of Health Sciences
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  • Alexander Link, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis
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  • Abraham G Goorhuis, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Hein W Verspaget, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Cyriel Ponsioen, Amsterdam University Medical Centers
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  • Georgina L Hold, St George and Sutherland Clinical School
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  • Herbert Tilg, Univ Klin Innsbruck, Medical University of Innsbruck
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  • Zain Kassam, Avellino Labs USA, Menlo Park, USA.
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  • Ed J Kuijper, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Antonio Gasbarrini, Italy.
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  • Chris Jj Mulder, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
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  • Horace Rt Williams, Imperial Coll London, Imperial College London, Imperial Clin Trials Unit
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  • Maria Jgt Vehreschild, Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

BACKGROUND: Fecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of feces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council.

OBJECTIVE: Several European and international consensus statements concerning fecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document.

METHODS: Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about fecal microbiota transplantation.

RESULTS: A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening.

CONCLUSION: The implementation of fecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor feces preparations for patients.

Original languageEnglish
JournalUnited European Gastroenterology Journal
Pages (from-to)2050640620967898
ISSN2050-6406
DOIs
Publication statusE-pub ahead of print - 5 Nov 2020

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